间充质干细胞来源的外泌体miR-145通过靶向JAM-A抑制动脉粥样硬化。
Mesenchymal stem-cell-derived exosomal miR-145 inhibits atherosclerosis by targeting JAM-A.
作者信息
Yang Wenzhi, Yin Ruihua, Zhu Xiaoyan, Yang Shaonan, Wang Jing, Zhou Zhenfeng, Pan Xudong, Ma Aijun
机构信息
Department of Neurology, The Affiliated Hospital of Qingdao University, Shandong 266100, China.
Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Shandong 266100, China.
出版信息
Mol Ther Nucleic Acids. 2020 Nov 4;23:119-131. doi: 10.1016/j.omtn.2020.10.037. eCollection 2021 Mar 5.
Atherosclerosis is a chronic inflammatory disease associated with the development of plaques that can be converted into an acute clinical event by thrombosis or plaque rupture. Mesenchymal stem cells (MSCs) exhibit therapeutic effects for the treatment of various diseases, including atherosclerosis. In this study, we show that microRNA-145 (miR-145) is associated with atherosclerosis by microRNA sequencing and bioinformatics analysis. MSC-derived miR-145-rich exosomes could efficiently deliver miR-145 from MSCs to human umbilical vein endothelial cells (HUVECs). Treatment of miR-145-rich exosomes could downregulate JAM-A, inhibit migration , and reduce atherosclerotic plaque . Our study suggests that MSC-derived miR-145-rich exosomes have great potential for atherosclerosis prevention.
动脉粥样硬化是一种慢性炎症性疾病，与斑块形成有关，这些斑块可通过血栓形成或斑块破裂转化为急性临床事件。间充质干细胞（MSCs）对包括动脉粥样硬化在内的各种疾病的治疗具有治疗作用。在本研究中，我们通过 microRNA 测序和生物信息学分析表明，microRNA-145（miR-145）与动脉粥样硬化有关。间充质干细胞来源的富含 miR-145 的外泌体可以有效地将 miR-145 从间充质干细胞传递到人脐静脉内皮细胞（HUVECs）。用富含 miR-145 的外泌体处理可下调 JAM-A，抑制迁移，并减少动脉粥样硬化斑块。我们的研究表明，间充质干细胞来源的富含 miR-145 的外泌体在预防动脉粥样硬化方面具有巨大潜力。
Zotero 插件