Banazadeh Maryam, Amirnejat Sara, Javanshir Shahrzad
Heterocyclic Chemistry Research Laboratory, Chemistry Department, Iran University of Science and Technology, Tehran, Iran.
Front Chem. 2020 Dec 1;8:596029. doi: 10.3389/fchem.2020.596029. eCollection 2020.
In this protocol, Fucoidan (FU), a fucose-rich sulfated polysaccharide extracted from brown algae Fucus vesiculosus was used for preparation of magnetic FeO@FU. Nanoco magnetic properties of FeO@FU were investigated by energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) adsorption method, and vibrating sample magnetometer (VSM). The catalytic activity of FeO@FU was employed for the synthesis of tri- and tetra-substituted imidazoles through three- and four-component reactions respectively, between benzyl, aldehydes, NHOAc and benzyl, aldehydes, NHOAc, and amine under reflux in ethanol. It is worth nothing that excellent yields, short reaction times, chromatography-free purification, and environmental friendliness are highlighted features of this protocol.
在本实验方案中，岩藻依聚糖（FU），一种从褐藻墨角藻中提取的富含岩藻糖的硫酸化多糖，被用于制备磁性FeO@FU。通过能量色散X射线（EDX）光谱、X射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）、场发射扫描电子显微镜（FESEM）、透射电子显微镜（TEM）、布鲁诺尔-埃米特-特勒（BET）吸附法和振动样品磁强计（VSM）研究了FeO@FU的纳米磁性。FeO@FU的催化活性分别用于通过苄基、醛、NHOAc之间的三组分反应以及苄基、醛、NHOAc和胺之间的四组分反应在乙醇回流条件下合成三取代和四取代咪唑。值得注意的是，本实验方案的突出特点是产率高、反应时间短、无需柱色谱纯化以及环境友好。
