Hong Christopher S, Gorrepati Ramana, Kundishora Adam J, Elsamadicy Aladine A, Peter Patricia R, Damisah Eyiyemisi C, Manes R Peter, Omay Sacit Bulent
Department of Neurosurgery, Yale School of Medicine, New Haven, CT, United States.
Section of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT, United States.
Front Surg. 2020 Dec 1;7:598138. doi: 10.3389/fsurg.2020.598138. eCollection 2020.
Seizures in patients with pituitary pathology are uncommon and typically secondary to electrolyte disturbances. Rarely, seizures have been described from mass effect related to large prolactinomas undergoing medical treatment. We describe a 54 year-old male who presented with a first-time generalized seizure, secondary to a pituitary macroadenoma compressing the left temporal lobe. His seizures abated after endoscopic endonasal debulking of the tumor. This report highlights isolated seizures as a potential sole presenting symptom of pituitary macroadenomas without visual or endocrine dysfunction. Prompt surgical debulking to relieve mass effect on the temporal lobe may effectively prevent further seizure activity.
垂体病变患者发生癫痫并不常见，通常继发于电解质紊乱。很少有因接受药物治疗的大泌乳素瘤的占位效应导致癫痫发作的报道。我们报告一名54岁男性，首次出现全身性癫痫发作，继发于垂体大腺瘤压迫左侧颞叶。在内镜下经鼻切除肿瘤后，他的癫痫发作得到缓解。本报告强调孤立性癫痫发作可能是垂体大腺瘤的唯一首发症状，而无视觉或内分泌功能障碍。及时进行手术切除以减轻对颞叶的占位效应，可能有效预防进一步的癫痫发作活动。
