骨保护素在腹主动脉瘤发生、发展及治疗中的作用
The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms.
作者信息
Migacz Maciej, Janoska-Gawrońska Agata, Holecki Michał, Chudek Jerzy
机构信息
Department and Clinic of Internal, Autoimmune and Metabolic Diseases, Faculty of Medicine, Medical University of Silesia in Katowice, Poland.
Department and Clinic of Internal Medicine and Cancer Chemotherapy, Faculty of Medicine, Medical University of Silesia in Katowice, Poland.
出版信息
Open Med (Wars). 2020 May 26;15(1):457-463. doi: 10.1515/med-2020-0046. eCollection 2020.
Osteoprotegerin (OPG) appears to be a very promising marker both in the diagnosis of abdominal aortic aneurysms (AAAs) and as a potential target in its treatment. This article presents an overview of the current literature that discusses the role of OPG in the pathogenesis of atherosclerosis and its potential value as a prognostic factor in AAA. Pharmacological modulation of OPG expression has been considered. In conclusion, it seems that further research designed to assess the relationship between OPG and AAA is needed as this may contribute to improved AAA monitoring and more effective treatment of patients with AAA.
骨保护素（OPG）似乎是腹主动脉瘤（AAA）诊断中非常有前景的标志物，也是其治疗的潜在靶点。本文概述了当前文献中关于OPG在动脉粥样硬化发病机制中的作用及其作为AAA预后因素的潜在价值的讨论。还考虑了对OPG表达的药理学调节。总之，似乎需要进一步开展研究来评估OPG与AAA之间的关系，因为这可能有助于改善AAA的监测，并更有效地治疗AAA患者。
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