MM College of Pharmacy, Maharishi Markandeshwer (Deemed to be University), Mullana, Ambala, India.
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India.
Drug Res (Stuttg). 2021 Feb;71(2):62-72. doi: 10.1055/a-1323-2813. Epub 2020 Dec 17.
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile structure, which has fascinated researchers to design novel piperazine based molecules having various biological actions. The subsistence of various compounds possessing diverse pharmacological activities in the literature further confirms this fact. Currently available analgesics and anti-inflammatory drugs are associated with side effects that limit their use. Moreover, the literature reveals the incredible anti-inflammatory and analgesic potential of piperazine derivatives along with their method of synthesis, therefore; the present review has been designed to collate the development made in this area that will surely be advantageous in designing novel piperazine based candidates with enhanced efficacy and less toxicity. An extensive literature survey was carried by scrutinizing peer reviewed articles from worldwide scientific databases available on GOOGLE, SCOPUS, PUBMED, and only relevant studies published in English were considered.
哌嗪，一种含氮杂环化合物，由于其多样的结构，在药物化学中获得了独特的地位，这引起了研究人员的兴趣，他们设计了各种具有不同生物活性的基于哌嗪的分子。文献中存在的具有多种药理活性的各种化合物进一步证实了这一事实。目前可用的镇痛药和抗炎药都有副作用，限制了它们的使用。此外，文献揭示了哌嗪衍生物具有令人难以置信的抗炎和镇痛潜力，以及它们的合成方法，因此；本综述旨在整理这一领域的发展，这必将有利于设计具有增强疗效和降低毒性的新型基于哌嗪的候选药物。通过仔细审查全球科学数据库中的同行评议文章，在 GOOGLE、SCOPUS、PUBMED 上进行了广泛的文献调查，只考虑了以英语发表的相关研究。
