Internal Medicine Nursing Department, Faculty of Nursing, Hacettepe University, Ankara, Turkey.
J Adv Nurs. 2021 Mar;77(3):1105-1126. doi: 10.1111/jan.14653. Epub 2020 Dec 17.
To analyse the different types of Aloe vera (AV) effects on various mucocutaneous problems among adults.
A systematic review and meta-analysis.
An exhaustive scanning of PubMed, Medline, ScienceDirect, and Google Scholar databases was conducted from January 2000-December 2019.
Randomized controlled trials (RCTs) publishing reports on the effects of AV in various mucocutaneous problems, psoriasis, burn, wound-healing were included. The standardized mean differences (SMD) with 95% confidence Intervals (CIs) were determined for the main outcomes, heterogeneity was analysed using the I test and the risk of bias in the studies was reviewed by the Cochrane risk of bias assessment tool.
The study included 23 trials with a total of 4,023 participants. Six trials were included in the meta-analysis. The results indicated no significant differences in pain scores as assessed by the Visual Analog Scale (VAS) (SMD = 0.11, 95% CI: -0.37 to 0.59). The Psoriasis Area Severity Index (PASI) scores were significantly lower following AV gel application in two of the studies (SMD = -1.32 95% CI: -1.86 to -0.78). Considering results in a systematic manner, AV accelerated tissue epithelialization and wound-healing process (N = 3), reduced oral mucositis (N = 3), and improved quality of life (N = 1).
AV might have beneficial effects in reducing pain scores and the severity of mucocutaneous problems compared with placebo, especially with limited mild to moderate adverse effects.
AV may be used as an alternative and integrative approach to reducing symptom severity in mucocutaneous problems and the wound-healing process. High quality and well-designed RCTs are still needed to elucidate the effects of AV in a variety of dosages and forms among adults with mucocutaneous problems.
分析不同类型的库拉索芦荟（AV）对成人各种黏膜皮肤问题的影响。
系统评价和荟萃分析。
从 2000 年 1 月至 2019 年 12 月，对 PubMed、Medline、ScienceDirect 和 Google Scholar 数据库进行了全面扫描。
纳入了报告 AV 对各种黏膜皮肤问题（银屑病、烧伤、伤口愈合）影响的随机对照试验（RCT）。主要结局的标准化均数差（SMD）和 95%置信区间（CI）采用 I 检验进行分析，采用 Cochrane 偏倚风险评估工具对研究中的偏倚风险进行了评估。
研究共纳入 23 项试验，共 4023 名参与者。其中 6 项试验纳入荟萃分析。结果表明，视觉模拟评分（VAS）评估的疼痛评分无显著差异（SMD=0.11，95%CI：-0.37 至 0.59）。两项研究中 AV 凝胶应用后银屑病面积严重指数（PASI）评分显著降低（SMD=-1.32，95%CI：-1.86 至-0.78）。综合考虑结果，AV 可加速组织上皮化和伤口愈合过程（N=3），减少口腔黏膜炎（N=3），提高生活质量（N=1）。
与安慰剂相比，AV 可能对减轻疼痛评分和黏膜皮肤问题的严重程度具有有益作用，特别是具有轻度至中度不良反应。
AV 可作为减轻黏膜皮肤问题和伤口愈合过程中症状严重程度的替代和综合方法。仍需要高质量和精心设计的 RCT 来阐明 AV 在各种剂量和形式下对成人黏膜皮肤问题的影响。
