At Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, Sonali Sharma is Research Intern; Allyson R. Alfonso, MD, is Surgical Resident; Alex J. Gordon, BS, is Medical Student; Jennifer Kwong, BA, is Research Fellow; Lawrence J. Lin, MD, is Surgical Resident; and Ernest S. Chiu, MD, FACS, is Attending Physician.
Adv Skin Wound Care. 2022 Nov 1;35(11):1-9. doi: 10.1097/01.ASW.0000875056.29059.78.
Aloe vera is a cost-effective, accessible wound care adjunct with a minimal risk profile. Despite its centuries-long history being used to treat varying wound types, published reports remain inconclusive on its efficacy. In this article, the authors report the results of a systematic review assessing the efficacy of topical aloe vera products in wound care applications, as well as a meta-analysis of its utility in burn healing where data are most robust.
In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, the authors searched PubMed, EMBASE, and Cochrane CENTRAL for randomized controlled trials assessing the use of aloe vera in healing various wound types.
The database search identified 91 articles. After duplicates were removed, 74 articles were screened, and of those, 47 were assessed for eligibility. Ultimately, 28 articles were included in the qualitative synthesis, and 4 studies assessing second-degree burns were included in the meta-analysis.
The following data points were collected from each study: number of participants/wounds, treatment type, adjunctive therapy (if any), and primary outcomes.
Risk-of-bias analysis was conducted on included articles, and results were compiled. A meta-analysis was undertaken for studies focusing on the treatment of burns. Cumulatively, these studies had a total of 133 patients with 163 wounds being assessed. Analysis revealed a statistically significant mean difference in time to healing of 4.44 days in favor of aloe vera treatment (P = .004).
Topical aloe vera usage for second-degree burn wound healing demonstrated significantly faster time to healing compared with other treatments.
库拉索芦荟是一种具有成本效益且易于获得的伤口护理辅助剂，其风险特征极小。尽管它具有数百年的历史，被用于治疗各种伤口类型，但已发表的报告仍未能确定其疗效。在本文中，作者报告了一项系统评价的结果，该评价评估了局部使用库拉索芦荟产品在伤口护理应用中的疗效，以及对烧伤愈合的荟萃分析，因为烧伤愈合的数据最为可靠。
根据 PRISMA（系统评价和荟萃分析的首选报告项目）指南，作者在 PubMed、EMBASE 和 Cochrane CENTRAL 中搜索了评估库拉索芦荟在治疗各种伤口类型中的使用的随机对照试验。
数据库搜索确定了 91 篇文章。去除重复项后，筛选了 74 篇文章，其中 47 篇文章进行了资格评估。最终，28 篇文章被纳入定性综合分析，4 项评估二度烧伤的研究被纳入荟萃分析。
从每项研究中收集以下数据点：参与者/伤口数量、治疗类型、辅助治疗（如有）和主要结局。
对纳入的文章进行了偏倚风险分析，并对结果进行了汇编。对专注于治疗烧伤的研究进行了荟萃分析。这些研究总共累计了 133 名患者的 163 个伤口进行了评估。分析显示，芦荟治疗组的愈合时间平均差异具有统计学意义，为 4.44 天（P =.004）。
与其他治疗方法相比，局部使用库拉索芦荟治疗二度烧伤伤口愈合的时间明显更快。
