Oral Health Prev Dent. 2022 Dec 12;20:509-516. doi: 10.3290/j.ohpd.b3666483.
To analyse the effects of aloe vera on the treatment of oral ulcers.
Relevant studies were identified from PubMed, Embase, ClinicalTrials.gov, SinoMed, Web of Science and Cochrane Library. Randomised controlled trials (RCTs) involving aloe vera (AV) in the treatment of oral ulcers were included. The data were extracted and pooled for meta-analysis to compare the clinical outcomes of patients with oral ulcers in terms of treatment effect, the size of ulcers, Visual Analogue Scale (VAS) for pain, and therapy duration. The standardised mean differences (SMD) with 95% confidence intervals (CI) were determined for the main outcomes, heterogeneity was analysed using the I2 test, and the studies' risk of bias was evaluating using the Cochrane risk of bias assessment tool.
The study included 9 trials with a total of 847 participants. Seven trials were included in the meta-analysis. The results indicated no statistically significant differences in pain scores as assessed by the VAS (I2 = 95%, p = 0.89; SMD: -0.12, 95% CI: -1.84, 1.60) and size of ulcers (I2 = 88%, p = 0.60; SMD: -0.29, 95% CI: -1.39, 0.81). Clinical efficacy of the aloe vera group was better compared to control group (I2 = 89%, p = 0.007; RR: 2.25, 95% CI: 1.25, 4.06). Therapy duration was statistically significantly lower following AV gel application in two of the studies (I2 = 0%, p < 0.001; SMD: -1.32, 95% CI: -1.84, -0.79). Considering the results in a systematic manner, AV accelerated tissue epithelialisation and the wound-healing process.
Compared with other interventions, aloe vera has a better therapeutic effect and shorter healing time. It is comparable with other interventions in relieving pain and reducing ulcer size, but it has higher safety and almost no side effects.
分析芦荟对口腔溃疡治疗的效果。
从PubMed、Embase、ClinicalTrials.gov、SinoMed、Web of Science 和 Cochrane Library 中检索到相关研究。纳入了涉及芦荟（AV）治疗口腔溃疡的随机对照试验（RCT）。提取数据并进行荟萃分析，比较口腔溃疡患者在治疗效果、溃疡大小、疼痛视觉模拟量表（VAS）评分和治疗持续时间方面的临床结局。主要结局采用标准化均数差（SMD）及其 95%置信区间（CI）表示，采用 I²检验分析异质性，采用 Cochrane 偏倚风险评估工具评价研究的偏倚风险。
研究纳入了 9 项共 847 名参与者的试验。其中 7 项试验纳入荟萃分析。结果显示，VAS 评估的疼痛评分（I²=95%，p=0.89；SMD：-0.12，95%CI：-1.84，1.60）和溃疡大小（I²=88%，p=0.60；SMD：-0.29，95%CI：-1.39，0.81）差异均无统计学意义。与对照组相比，芦荟组的临床疗效更好（I²=89%，p=0.007；RR：2.25，95%CI：1.25，4.06）。有两项研究中，应用 AV 凝胶后治疗持续时间有统计学意义的降低（I²=0%，p<0.001；SMD：-1.32，95%CI：-1.84，-0.79）。综合系统评价结果，芦荟能加速组织上皮化和伤口愈合过程。
与其他干预措施相比，芦荟具有更好的治疗效果和更短的愈合时间。在缓解疼痛和减少溃疡大小方面与其他干预措施相当，但安全性更高，几乎没有副作用。
