Centre for Reproductive Medicine, Antwerp University Hospital, Edegem, Belgium.
University of Antwerp, Wilrijk, Belgium.
Andrology. 2021 May;9(3):846-853. doi: 10.1111/andr.12963. Epub 2021 Jan 26.
A recent meta-regression analysis reported a temporal trend in sperm count showing a significant decline in sperm count between 1973 and 2011. This decline is thought to affect fecundity. Moreover, semen quality is considered of key interest to public health given its association with all-cause male morbidity/mortality. The issue requires ongoing investigation due to geographical variation in semen quality and methodological errors in semen analysis.
To study whether there is a temporal trend in semen quality in Belgian candidate sperm donors and in sperm donors' fertility potential.
Retrospective analysis of samples provided by 439 candidate donors and pregnancy outcome in acceptors over a period of 23 years.
A total of 807 specimens from 439 candidate donors were examined from January 1995 to December 2017 (Table S1). Sub-analyses performed with regard to TSC from 2010 onwards (weighing) revealed a significant negative trend (R =-0.033; β=-0.18; CI: -0.16 to 0.07; p < 0.05). We found a statistically significant association between year of donation and morphology (R = 0.036; β= -0.19; CI: -0.26 to -0.08; p < 0.0001). The mean (±SD) clinical pregnancy rate per effective donor recruited (n = 104), defined as the number of women with a clinical pregnancy, per number of women who initiated treatment with a donor's spermatozoa, was 68.5 (± 24.9) %. This measure did not show a significant change in function of year of donation.
Candidate sperm donors represent a select group of men; as such, these results are not to be interpreted as representative for the general population.
The study did not show a significant change in sperm concentration or fertility potential in sperm donors over a period of 23 years. However, a negative trend was found for TSC from 2010 onwards. Also, the results show a significant decrease in ideal morphology over time.
最近的一项荟萃回归分析报告显示，精子数量存在时间趋势，在 1973 年至 2011 年间，精子数量显著下降。这种下降被认为会影响生育能力。此外，由于精液质量分析方法存在误差，且与男性全因发病率/死亡率相关，因此精液质量被认为是公共卫生的关键关注点。由于精液质量存在地域差异，且精液分析方法存在误差，该问题需要持续研究。
研究比利时候选精子供体的精液质量是否存在时间趋势，以及精子供体的生育能力是否存在时间趋势。
对 23 年间 439 名候选供体的样本进行回顾性分析，并对接受者的妊娠结局进行分析。
1995 年 1 月至 2017 年 12 月期间共检查了 439 名候选供体的 807 份样本（表 S1）。对 2010 年以后的 TSC 进行亚分析（称重）显示，存在显著的负向趋势（R=-0.033；β=-0.18；CI：-0.16 至 0.07；p<0.05）。我们发现，捐赠年份与形态学之间存在统计学显著关联（R=0.036；β=-0.19；CI：-0.26 至 -0.08；p<0.0001）。根据招募的有效供体（定义为接受供体精子治疗的妇女数量）的临床妊娠率计算（n=104），每位有效供体的平均（±SD）临床妊娠率为 68.5（±24.9）%。该指标与捐赠年份无显著变化。
候选精子供体代表了一个特定的男性群体；因此，这些结果不能被解释为代表一般人群。
在 23 年的时间里，精子供体的精子浓度或生育能力没有显著变化。然而，从 2010 年开始，TSC 呈现出负向趋势。此外，结果显示理想形态随时间显著下降。
