环戊烷 FIT-PNAs：明亮的 RNA 传感器。
Cyclopentane FIT-PNAs: bright RNA sensors.
机构信息
The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel.
出版信息
Chem Commun (Camb). 2021 Jan 14;57(4):540-543. doi: 10.1039/d0cc07400d. Epub 2020 Dec 18.
PMID:33336664
Abstract
Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
摘要
环戊烷修饰的 FIT-PNA (cpFIT-PNA) 探针被报道为具有高荧光性的 RNA 传感器，其荧光强度为 FIT-PNA 中最高。与 FIT-PNAs 相比，cpFIT-PNAs 对几种嘧啶-嘧啶单核苷酸变体 (SNVs) 的错配识别能力有所提高。
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