Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland.
Biological Sciences Program - Molecular and Cellular Biology, University of Maryland, College Park, Maryland.
Compr Rev Food Sci Food Saf. 2020 Jul;19(4):1908-1933. doi: 10.1111/1541-4337.12565. Epub 2020 May 26.
The bioactive ingredients in commonly consumed foods include, but are not limited to, prebiotics, prebiotic-like components, probiotics, and postbiotics. The bioactive ingredients in functional foods have also been associated with beneficial effects on human health. For example, they aid in shaping of gut microflora and promotion of immunity. These functional components also contribute in preventing serious diseases such as cardiovascular malfunction and tumorigenesis. However, the specific mechanisms of these positive influences on human health are still under investigation. In this review, we aim to emphasize the major contents of probiotics, prebiotics, and prebiotic-like components commonly found in consumable functional foods, and we present an overview of direct and indirect benefits they provide on human health. The major contributors are certain families of metabolites, specifically short-chain fatty acids and polyunsaturated fatty acids produced by probiotics, and prebiotics, or prebiotic-like components such as flavonoids, polyphenols, and vitamins that are found in functional foods. These functional ingredients in foods influence the gut microbiota by stimulating the growth of beneficial microbes and the production of beneficial metabolites that, in turn, have direct benefits to the host, while also providing protection from pathogens and maintaining a balanced gut ecosystem. The complex interactions that arise among functional food ingredients, human physiology, the gut microbiota, and their respective metabolic pathways have been found to minimize several factors that contribute to the incidence of chronic disease, such as inflammation oxidative stress.
常见食用食物中的生物活性成分包括但不限于益生元、类益生元成分、益生菌和后生元。功能性食品中的生物活性成分也与对人类健康的有益影响有关。例如,它们有助于塑造肠道微生物群并促进免疫力。这些功能性成分还有助于预防心血管功能障碍和肿瘤发生等严重疾病。然而,这些对人类健康的积极影响的确切机制仍在研究中。在这篇综述中,我们旨在强调可食用功能性食品中常见的益生菌、益生元和类益生元成分的主要内容,并概述它们对人类健康的直接和间接益处。主要贡献者是某些代谢物家族,特别是益生菌和益生元产生的短链脂肪酸和多不饱和脂肪酸,以及功能性食品中发现的类黄酮、多酚和维生素等类益生元成分。这些食品中的功能性成分通过刺激有益微生物的生长和有益代谢产物的产生来影响肠道微生物群,从而直接有益于宿主,同时还可以防止病原体的侵害并维持肠道生态系统的平衡。功能性食品成分、人类生理学、肠道微生物群及其各自代谢途径之间的复杂相互作用已被发现可最大程度地减少导致慢性疾病发生的几个因素,如炎症和氧化应激。