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保持纳米医学的靶向性。

Keeping Nanomedicine on Target.

机构信息

Laboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

出版信息

Nano Lett. 2021 Jan 13;21(1):3-5. doi: 10.1021/acs.nanolett.0c04638. Epub 2020 Dec 18.

DOI:10.1021/acs.nanolett.0c04638
PMID:33337166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8005263/
Abstract

A principal purpose of targeting or triggering is to improve the active agents’ therapeutic indices by preferentially increasing their concentrations at the desired site of effect.

摘要

靶向或触发的主要目的是通过优先增加活性药物在所需作用部位的浓度来提高其治疗指数。

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Keeping Nanomedicine on Target.保持纳米医学的靶向性。
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本文引用的文献

1
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia.光触发从大分子前药中释放常规局部麻醉剂,用于按需局部麻醉。
Nat Commun. 2020 May 8;11(1):2323. doi: 10.1038/s41467-020-16177-w.
2
Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine.药物传递中主动靶向纳米粒子的新见解:癌症纳米医学的临床研究进展和设计考虑因素。
Bioconjug Chem. 2019 Sep 18;30(9):2300-2311. doi: 10.1021/acs.bioconjchem.9b00456. Epub 2019 Sep 6.
3
Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles.光靶向纳米颗粒静脉治疗脉络膜新生血管。
Nat Commun. 2019 Feb 18;10(1):804. doi: 10.1038/s41467-019-08690-4.
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Progress in Nanomedicine: Approved and Investigational Nanodrugs.纳米医学进展:已获批和正在研究的纳米药物
P T. 2017 Dec;42(12):742-755.
5
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.基于纳米颗粒的药物:对美国食品药品监督管理局(FDA)批准的材料及迄今临床试验的综述。
Pharm Res. 2016 Oct;33(10):2373-87. doi: 10.1007/s11095-016-1958-5. Epub 2016 Jun 14.
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Phototriggered Local Anesthesia.光触发局部麻醉。
Nano Lett. 2016 Jan 13;16(1):177-81. doi: 10.1021/acs.nanolett.5b03440. Epub 2015 Dec 14.
7
Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity.为了充分了解原发性和转移性肿瘤中的 EPR 效应以及与其异质性相关的问题。
Adv Drug Deliv Rev. 2015 Aug 30;91:3-6. doi: 10.1016/j.addr.2015.01.002. Epub 2015 Jan 9.
8
Near-infrared-actuated devices for remotely controlled drug delivery.近红外光驱动的远程控制药物输送装置。
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1349-54. doi: 10.1073/pnas.1322651111. Epub 2014 Jan 13.
9
Ultrasound guidance for deep peripheral nerve blocks: a brief review.超声引导下深部周围神经阻滞:简要综述。
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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.利用肿瘤微环境:用于抗癌药物输送的纳米载体的被动和主动肿瘤靶向。
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