Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Université Libre de Bruxelles, Brussels, Belgium.
Belgium Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.
United European Gastroenterol J. 2021 Mar;9(2):220-228. doi: 10.1177/2050640620980713. Epub 2021 Feb 16.
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens clinical outcomes in patients with chronic liver diseases. It is a common complication in hospitalised patients with liver cirrhosis, especially those with decompensated cirrhosis, associated with a high mortality rate. Considering its impact on patient prognosis, efforts should be made to diagnose and tailor therapeutic interventions for AKI at an early stage. In the past decade, a significant progress has been made to understand the key events and define major prognostic factors for the onset and progression of AKI in the cirrhotic population leading hepatologists to redefine the classic definition of hepatorenal syndrome and renal failure in this specific population.
急性肾损伤（AKI）是一种临床综合征，可使慢性肝病患者的病程复杂化并导致其临床结局恶化。它是肝硬化住院患者的常见并发症，特别是失代偿性肝硬化患者，与高死亡率相关。鉴于其对患者预后的影响，应努力在早期诊断和调整 AKI 的治疗干预措施。在过去十年中，人们对肝硬化患者 AKI 发生和进展的关键事件和主要预后因素有了更深入的了解，这促使肝病学家重新定义了该特定人群中肝肾综合征和肾衰竭的经典定义。
