Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Department of Sport Research, Japan Institute of Sports Sciences, Tokyo, Japan.
J Strength Cond Res. 2021 Feb 1;35(2):360-365. doi: 10.1519/JSC.0000000000003923.
Tanabe, Y, Shimizu, K, Kondo, E, Yasumatsu, M, Nakamura, D, Sagayama, H, and Takahashi, H. Urinary N-terminal fragment of titin reflects muscle damage after a soccer match in male collegiate soccer players. J Strength Cond Res 35(2): 360-365, 2021-Previous studies have demonstrated that noninvasive urinary N-terminal fragment of titin (U-titin) concentration highly correlates with serum creatine kinase (CK) activity, a classic invasive muscle damage marker. This finding indicates that U-titin could be used to estimate muscle damage. However, these results were achieved using a laboratory-based eccentric exercise model. Therefore, it remains unclear whether U-titin is useful for evaluating muscle damage occurring in field sports events. As a result, we evaluated whether U-titin concentration closely relates to serum CK activity after a soccer match. Seventeen collegiate soccer players (age: 20 ± 1 year; height: 172 ± 6 cm; body mass: 65 ± 5 kg; Yo-Yo intermittent recovery test level 2, 1,135 ± 196 m) completed a test match (2 halves of 45 minutes separated by 15 minutes of normal half-time). U-titin concentration, serum CK activity, countermovement jump performance, and muscle soreness were assessed 2 hours before the match and 30 minutes, 24 hours, and 48 hours after the match. U-titin concentrations and CK activity similarly increased at 24 hours and returned to the baseline value at 48 hours after the match. Moreover, the percentage of changes in U-titin concentration from baseline after the match significantly and positively correlated with serum CK activity (r = 0.82, p < 0.05). These results suggest that the noninvasive marker U-titin can be used to assess muscle damage conditions in field sports events, such as soccer matches.
谷部，Y.，清水，K.，近藤，E.，安松，M.，中村，D.，笹山，H.，高桥，H.。男性大学生足球运动员比赛后尿液中的肌联蛋白 N 端片段反映肌肉损伤。《力量与调节研究杂志》35（2）：360-365，2021-之前的研究表明，非侵入性尿肌联蛋白 N 端片段（U-titin）浓度与血清肌酸激酶（CK）活性高度相关，CK 是一种经典的侵袭性肌肉损伤标志物。这一发现表明 U-titin 可用于估计肌肉损伤。然而，这些结果是使用基于实验室的离心运动模型获得的。因此，尚不清楚 U-titin 是否可用于评估在野外运动赛事中发生的肌肉损伤。因此，我们评估了在足球比赛后 U-titin 浓度是否与血清 CK 活性密切相关。17 名大学生足球运动员（年龄：20±1 岁；身高：172±6cm；体重：65±5kg；Yo-Yo 间歇性恢复测试水平 2，1,135±196m）完成了一场测试赛（2 个 45 分钟的半场，中间有 15 分钟的正常中场休息）。在比赛前 2 小时和比赛后 30 分钟、24 小时和 48 小时评估 U-titin 浓度、血清 CK 活性、反跳跳高度和肌肉酸痛。U-titin 浓度和 CK 活性在 24 小时时同样增加，并在比赛后 48 小时恢复到基线值。此外，比赛后 U-titin 浓度从基线的变化百分比与血清 CK 活性显著正相关（r=0.82，p<0.05）。这些结果表明，非侵入性标志物 U-titin 可用于评估足球等野外运动赛事中的肌肉损伤情况。
