Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Cell. 2021 Jan 7;184(1):15-17. doi: 10.1016/j.cell.2020.12.003. Epub 2020 Dec 17.
Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other coronaviruses enhances our understanding of the cellular life cycle of this medically important family of emerging viruses.
多个团队进行的互补性全基因组 CRISPR-Cas9 筛选揭示了 SARS-CoV-2 生物学的新见解，包括病毒进入、翻译、复制、出芽和调节这些过程的基因等方面。与其他冠状病毒的比较增强了我们对这一具有医学重要性的新兴病毒家族的细胞生命周期的理解。
