Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eur J Radiol. 2021 Feb;135:109470. doi: 10.1016/j.ejrad.2020.109470. Epub 2020 Dec 5.
The cavum septum pellucidum (CSP) is an important landmark in the evaluation of the fetal neural axis. A deviation from the ultrasonic normal values may be associated with unfavorable outcomes, and a normal CSP provides reassurance of normal central forebrain development. Today, there is biometric data regarding the normal values for the width of the CSP in fetal ultrasound, but there is no such data for fetal MRI. The aim of this study was to determine the normal values for the measurements of the fetal CSP on MRI.
We retrospectively examined 307 MRI scans of fetuses between 25 and 41 weeks gestation. Data was collected from the electronic charts of patients who underwent fetal MR imaging at a single tertiary Medical Center. The width and length of the CSP were measured in the axial plane, and the width and height were measured in the coronal plane.
The width and height of the CSP in fetuses tend to decrease starting from the 27th week of gestation onwards. High levels of intraobserver and interobserver agreements were calculated. The sex of the fetus does not appear to influence the biometry of the CSP.
This study provides MRI reference values for the dimensions of the CSP starting from the 25th week of gestation. Knowing the normal values for MRI could provide valuable information for researchers and in the decision-making process in patient's consultations.
透明隔腔（CSP）是评估胎儿神经轴的重要标志。偏离超声正常值可能与不良结局相关，而正常的 CSP 可确保正常的中脑前脑发育。如今，已有关于胎儿超声中 CSP 宽度的正常生物测量值的数据，但胎儿 MRI 中尚无此类数据。本研究旨在确定 MRI 测量胎儿 CSP 的正常值。
我们回顾性分析了 307 例 25 至 41 孕周胎儿的 MRI 扫描。这些数据来自于在一家三级医疗中心接受胎儿磁共振成像的患者电子病历中收集而来。在轴位平面上测量 CSP 的宽度和长度，在冠状位平面上测量 CSP 的宽度和高度。
胎儿的 CSP 宽度和高度从 27 孕周开始逐渐减小。观察者内和观察者间的高度一致性。胎儿的性别似乎不会影响 CSP 的生物测量。
本研究提供了从 25 孕周开始的 CSP 尺寸的 MRI 参考值。了解 MRI 的正常值可为研究人员提供有价值的信息，并在患者咨询的决策过程中提供帮助。
