仅口服伏立康唑治疗真菌性角膜炎：病例系列研究。
Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series.
机构信息
Department of Ophthalmology, Guangxi Medical University First Affiliated Hospital, Nanning, China.
出版信息
Klin Monbl Augenheilkd. 2021 Jan;238(1):55-59. doi: 10.1055/a-1268-9168. Epub 2020 Dec 18.
BACKGROUND
To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis.
HISTORY AND SIGNS
Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 200 mg twice daily to observe the clinical response in the treatment of fungal keratitis.
THERAPY AND OUTCOME
The mean age of the patients was 51 years and the average treatment duration was 6 weeks. The corneal inflammation in these three patients was eliminated by oral voriconazole only.
CONCLUSIONS
This is the first reported case of oral voriconazole only as a treatment for fungal keratitis. We found that oral voriconazole has a significant clinical effect on the treatment of fungal keratitis.
背景
报告仅口服伏立康唑治疗真菌性角膜炎的临床疗效。
病史和体征
本研究纳入 3 例（1 例毛霉科、1 例曲霉属、1 例镰刀菌属）培养证实的真菌性角膜炎患者。给予患者口服伏立康唑 200mg，每日 2 次，观察其治疗真菌性角膜炎的临床疗效。
治疗及结果
患者的平均年龄为 51 岁，平均治疗时间为 6 周。仅口服伏立康唑即消除了这 3 例患者的角膜炎症。
结论
这是首例报告的仅口服伏立康唑治疗真菌性角膜炎的病例。我们发现，口服伏立康唑对治疗真菌性角膜炎具有显著的临床疗效。
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