Lee Sang Joon, Lee Jung Joo, Kim Shin Dong
Department of Ophthalmology, College of Medicine, Kosin University, Busan, Korea.
Korean J Ophthalmol. 2009 Mar;23(1):46-8. doi: 10.3341/kjo.2009.23.1.46. Epub 2009 Mar 9.
We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
我们描述了两名对标准抗真菌治疗无效的真菌性角膜炎患者，他们的病情通过伏立康唑得到了控制。第一例是一名在接受角膜移植后发生近平滑念珠菌性眼内炎和角膜溃疡的患者。该患者接受了两性霉素治疗，但没有改善的迹象。局部使用伏立康唑、口服伏立康唑和玻璃体内注射伏立康唑均出现了改善的迹象。第二例是一名63岁男性，他因真菌性角膜炎接受了为期一个月的0.2%局部两性霉素经验性治疗，但没有改善的迹象。随后给予1%伏立康唑治疗。两例患者使用伏立康唑治疗均有效。伏立康唑可被视为治疗对标准抗真菌治疗无效的真菌性角膜炎的一种新方法。
