Shehata Abdelrazeq M, Saadeldin Islam M, Tukur Hammed A, Habashy Walid S
Department of Animal Production, Faculty of Agriculture, Al-Azhar University, Cairo 11651, Egypt.
Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India.
Animals (Basel). 2020 Dec 16;10(12):2407. doi: 10.3390/ani10122407.
Heat stress is one of the most challenging environmental stresses affecting domestic animal production, particularly commercial poultry, subsequently causing severe yearly economic losses. Heat stress, a major source of oxidative stress, stimulates mitochondrial oxidative stress and cell dysfunction, leading to cell damage and apoptosis. Cell survival under stress conditions needs urgent response mechanisms and the consequent effective reinitiation of cell functions following stress mitigation. Exposure of cells to heat-stress conditions induces molecules that are ready for mediating cell death and survival signals, and for supporting the cell's tolerance and/or recovery from damage. Heat-shock proteins (HSPs) confer cell protection against heat stress via different mechanisms, including developing thermotolerance, modulating apoptotic and antiapoptotic signaling pathways, and regulating cellular redox conditions. These functions mainly depend on the capacity of HSPs to work as molecular chaperones and to inhibit the aggregation of non-native and misfolded proteins. This review sheds light on the key factors in heat-shock responses for protection against cell damage induced by heat stress in chicken.
热应激是影响家畜生产尤其是商业家禽养殖的最具挑战性的环境应激之一，随后会造成严重的年度经济损失。热应激是氧化应激的主要来源，会刺激线粒体氧化应激和细胞功能障碍，导致细胞损伤和凋亡。应激条件下的细胞存活需要紧急反应机制，并在应激缓解后有效重新启动细胞功能。将细胞暴露于热应激条件会诱导一些分子，这些分子可介导细胞死亡和存活信号，并支持细胞的耐受性和/或从损伤中恢复。热休克蛋白（HSPs）通过不同机制赋予细胞抗热应激保护作用，包括形成耐热性、调节凋亡和抗凋亡信号通路以及调节细胞氧化还原状态。这些功能主要取决于热休克蛋白作为分子伴侣发挥作用以及抑制非天然和错误折叠蛋白质聚集的能力。本综述揭示了鸡热休克反应中针对热应激诱导的细胞损伤进行保护的关键因素。
