Patel Bhavik Y, White Laura, Gavriilidis Paschalis, Satyadas Thomas, Frampton Adam E, Pai Madhava
HPB Surgical Unit, Dept. of Surgery & Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK.
Manchester Royal Infirmary, Manchester University Foundation Trust, Manchester, UK.
Eur J Surg Oncol. 2021 May;47(5):970-978. doi: 10.1016/j.ejso.2020.11.146. Epub 2020 Dec 8.
Pancreaticoduodenectomy is associated with high rates of morbidity. This combined with the psychological burden of cancer, may impact on a patient's quality of life (QoL), which can be measured by using patient-reported outcomes (PRO).
To perform a systematic review to evaluate the measurement of PRO after pancreaticoduodenectomy for cancer.
7 different databases were searched using 2 groups of search terms, one relating to pancreaticoduodenectomy, and one to PRO. Three authors screened the search results independently in a systematic manner based on predefined inclusion and exclusion criteria.
27 studies, with 2173 eligible patients were included in the final analysis. Most of the included studies used validated instruments. The European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire was most popular and used in 12 studies. The methodology of all included studies was also scrutinised. 12 studies were deemed to have high quality methodology according to pre-defined criteria.
The instruments and methods used to measure PRO are variable. The quality of PRO within the available literature has improved over time, as has the number of studies measuring PRO. PRO should be measured with uniformity in future trials so that patients can be provided with more comprehensive information regarding post-operative recovery and QoL during the shared decision-making process preoperatively.
胰十二指肠切除术的发病率较高。这与癌症带来的心理负担相结合，可能会影响患者的生活质量（QoL），而这可以通过患者报告结局（PRO）来衡量。
进行一项系统评价，以评估癌症患者胰十二指肠切除术后PRO的测量情况。
使用两组检索词对7个不同的数据库进行检索，一组与胰十二指肠切除术相关，另一组与PRO相关。三位作者根据预先定义的纳入和排除标准，以系统的方式独立筛选检索结果。
最终分析纳入了27项研究，共2173例符合条件的患者。大多数纳入研究使用了经过验证的工具。欧洲癌症研究与治疗组织（EORTC）QLQ-C30问卷最受欢迎，有12项研究使用了该问卷。所有纳入研究的方法也都经过了审查。根据预先定义的标准，有12项研究被认为具有高质量的方法。
用于测量PRO的工具和方法各不相同。随着时间的推移，现有文献中PRO的质量有所提高，测量PRO的研究数量也有所增加。在未来的试验中，应该统一测量PRO，以便在术前的共同决策过程中，能够为患者提供关于术后恢复和生活质量的更全面信息。
