Zhu W, Yang Y, Zhao Y, Tang H, Zhang X, Shi R, Zhao Y, Han R
Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, 295, Xinwen road, 650032 Yunnan, China.
Department of Endocrinology, Kunming second people's hospital, 42, Ciba North road, Yunnan, China.
Arch Pediatr. 2021 Jan;28(1):96-100. doi: 10.1016/j.arcped.2020.10.016. Epub 2020 Dec 16.
Primary hypothyroidism can lead to delayed growth and pseudoprecocious puberty in juvenile patients, which was known as Van Wyk-Grumbach's syndrome (VWGS). There have been very few clinical case reports of primary juvenile hypothyroidism presenting with concurrent huge bilateral cystic ovaries. Here, we report the case of a 14-year-old female patient suffering from primary hypothyroidism in combination with bilateral cystic ovaries. Remarkable improvement of symptoms was observed after one month of hormone replacement therapy and an unnecessary surgical treatment was avoided. A comprehensive literature review of VWGS is summarised here to illustrate the presentation, diagnosis, and treatment of VWGS in pediatric patients. The present study aims to improve the current clinical knowledge of VWGS.
原发性甲状腺功能减退症可导致青少年患者生长发育迟缓及假性性早熟，这被称为范·怀克-格伦巴赫综合征（VWGS）。原发性青少年甲状腺功能减退症并发双侧巨大囊性卵巢的临床病例报告非常少见。在此，我们报告一例14岁女性原发性甲状腺功能减退症合并双侧囊性卵巢的病例。经过一个月的激素替代治疗后症状明显改善，避免了不必要的手术治疗。本文总结了对VWGS的全面文献综述，以阐述儿科患者VWGS的临床表现、诊断和治疗。本研究旨在提高目前对VWGS的临床认识。
