School of Natural Sciences, Bangor University, Bangor, UK.
Department of Chemistry, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu Province, P.R. China.
Physiol Rep. 2021 Jan;8(24):e14644. doi: 10.14814/phy2.14644.
This review examines the stress hormone cortisol which plays an important role in regulating and supporting different bodily functions. Disruption in cortisol production has an impact on health and this review looks at a wide range of papers where cortisol has been indicated as a factor in numerous chronic conditions-especially those which are classed as "noncommunicable diseases" (NCDs). Timely detection, screening, and treatment for NCDs are vital to address the growing problem of NCDs worldwide-this would have health and socioeconomic benefits. Interestingly, many of the papers highlight the pro-inflammatory consequences of cortisol dysregulation and its deleterious effects on the body. This is particularly relevant given the recent findings concerning COVID-19 where pro-inflammatory cytokines have been implicated in severe inflammation.
本文综述了应激激素皮质醇，它在调节和支持身体各项功能方面发挥着重要作用。皮质醇的产生受到干扰会对健康产生影响，本综述考察了大量文献，这些文献表明皮质醇是许多慢性疾病（尤其是被归类为“非传染性疾病”（NCD）的疾病）的一个因素。及时发现、筛查和治疗 NCD 对于解决全球 NCD 问题至关重要，这将带来健康和社会经济效益。有趣的是，许多文献强调了皮质醇失调的促炎后果及其对身体的有害影响。鉴于最近关于 COVID-19 的研究结果，其中促炎细胞因子与严重炎症有关，这一点尤其重要。
