Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, the Netherlands.
Hannover Medical School, Department of Obstetrics and Gynecology, Hannover, Germany.
Mol Cell Endocrinol. 2021 Feb 15;522:111118. doi: 10.1016/j.mce.2020.111118. Epub 2020 Dec 17.
Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is released in significant amounts from the ovary and uteroplacental unit. This review describes the sources of prorenin in the periconception period and in pregnancy, including its modulation by in-vitro fertilization protocols, and discusses its potential effects, among others focusing on preeclampsia. It ends with discussing the long-term consequences, even in later life, of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and offers directions for future research. Ultimately, a full understanding of the role of prorenin periconceptionally and during pregnancy will help to develop tools to diagnose and/or prevent reproductive complications.
妊娠需要心血管、肾脏和内分泌系统的重大变化，为不断生长的胎儿提供充足的血液供应。肾素-血管紧张素-醛固酮系统在这一适应过程中起着关键作用。其组成部分之一的原肾素大量从卵巢和胎盘单位释放出来。本文综述了原肾素在围孕期和妊娠期间的来源，包括其通过体外受精方案的调节，并讨论了其潜在的影响，特别是在子痫前期方面。最后讨论了妊娠期间肾素-血管紧张素-醛固酮系统活性不当的长期后果，甚至在以后的生活中，以及为未来的研究提供了方向。最终，全面了解原肾素在围孕期和妊娠期间的作用将有助于开发诊断和/或预防生殖并发症的工具。
