Wiegel Rosalieke E, von Versen-Höynck Frauke, Steegers-Theunissen Régine P M, Steegers Eric A P, Danser A H Jan
Departments of Obstetrics and Gynecology, Erasmus MC, Rotterdam, the Netherlands.
Hannover Medical School, Department of Obstetrics and Gynecology, Hannover, Germany.
Mol Cell Endocrinol. 2021 Jun 1;529:111281. doi: 10.1016/j.mce.2021.111281. Epub 2021 Apr 18.
Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is released in significant amounts from the ovary and uteroplacental unit. This review describes the sources of prorenin in the periconception period and in pregnancy, including its modulation by in-vitro fertilization protocols, and discusses its potential effects, among others focusing on preeclampsia. It ends with discussing the long-term consequences, even in later life, of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and offers directions for future research. Ultimately, a full understanding of the role of prorenin periconceptionally and during pregnancy will help to develop tools to diagnose and/or prevent reproductive complications.
妊娠需要心血管、肾脏和内分泌系统发生重大变化，以便为不断生长的胎儿提供充足的血液供应。肾素-血管紧张素-醛固酮系统在这一适应过程中起关键作用。其组成部分之一，即前肾素，大量从卵巢和子宫胎盘单位释放。本综述描述了受孕前期和妊娠期前肾素的来源，包括其受体外受精方案的调节，并讨论了其潜在影响，尤其聚焦于子痫前期。最后讨论了妊娠期间肾素-血管紧张素-醛固酮系统活动异常的长期后果，甚至包括对晚年生活的影响，并为未来研究提供了方向。最终，全面了解受孕前期和妊娠期前肾素的作用将有助于开发诊断和/或预防生殖并发症的工具。
