Padova Neuroscience Center, University of Padova, Italy; Department of Neuroscience, University of Padova, Italy.
Padova Neuroscience Center, University of Padova, Italy; Department of Neuroscience, University of Padova, Italy.
Exp Gerontol. 2021 Mar;145:111216. doi: 10.1016/j.exger.2020.111216. Epub 2020 Dec 16.
Subjective cognitive decline (SCD) has been proposed as a preclinical stage of Alzheimer's disease (AD). Neuroimaging studies have suggested early AD-like structural brain alterations in SCD subjects compared to healthy controls. However, there is substantial heterogeneity in the results, which might depend on whether SCD samples were drawn from the community or from memory clinics. Here we reviewed brain atrophy, assessed through structural magnetic resonance imaging, separately for SCD-community and clinic-based samples. SCD-community samples show a more consistent pattern of atrophy, involving the hippocampus and temporal and parietal cortices. Similarly, in SCD-clinic samples the temporo-parietal cortex showed early vulnerability, however these studies reported a more heterogeneous atrophy pattern. Overall, these studies suggest both commonalities and differences in brain atrophy patterns between SCD clinical and community samples. In SCD-community, the temporal cortex is involved, while SCD-clinical exhibited a more complex pattern of atrophy, which may be related to a more heterogeneous sample reporting neuropsychiatric symptoms along with preclinical AD.
主观认知衰退（SCD）被认为是阿尔茨海默病（AD）的临床前阶段。神经影像学研究表明，与健康对照组相比，SCD 受试者存在早期类似 AD 的结构性脑改变。然而，结果存在很大的异质性，这可能取决于 SCD 样本是来自社区还是记忆诊所。在这里，我们分别回顾了 SCD-社区和基于诊所的样本中通过结构磁共振成像评估的脑萎缩。SCD-社区样本显示出更一致的萎缩模式，涉及海马体以及颞叶和顶叶皮层。同样，在 SCD-诊所样本中，颞顶叶皮层表现出早期的脆弱性，但这些研究报告了更具异质性的萎缩模式。总的来说，这些研究表明 SCD 临床和社区样本之间的脑萎缩模式既有共同性也有差异。在 SCD-社区中，颞叶皮层受累，而 SCD-临床则表现出更复杂的萎缩模式，这可能与更具异质性的样本有关，这些样本除了有临床前 AD 外，还报告了神经精神症状。
