弗林蛋白酶切割位点在冠状病毒中天然存在。
Furin cleavage sites naturally occur in coronaviruses.
作者信息
Wu Yiran, Zhao Suwen
机构信息
iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
出版信息
Stem Cell Res. 2020 Dec 9;50:102115. doi: 10.1016/j.scr.2020.102115.
The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.
刺突蛋白是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的全球大流行疾病 COVID-19的重点研究对象。刺突编码序列中S1/S2处12个核苷酸的插入产生了一个弗林蛋白酶切割位点，这引发了关于该病毒起源的争议性观点。在此，我们分析了冠状病毒刺突蛋白的系统发育关系，并在树上绘制了弗林蛋白酶识别基序。弗林蛋白酶切割位点在冠状病毒家族的进化过程中多次独立出现，这支持了SARS-CoV-2的自然发生假说。
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