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Prev Med Rep. 2023 Jun 25;35:102302. doi: 10.1016/j.pmedr.2023.102302. eCollection 2023 Oct.
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Impact of the COVID-19 pandemic on routine vaccine landscape: A global perspective.COVID-19 大流行对常规疫苗接种情况的影响:全球视角。
Hum Vaccin Immunother. 2023 Dec 31;19(1):2199656. doi: 10.1080/21645515.2023.2199656. Epub 2023 Apr 20.
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Harnessing the Natural Toxic Metabolites in COVID-19.利用新冠病毒中的天然有毒代谢产物
Evid Based Complement Alternat Med. 2022 Mar 7;2022:3954944. doi: 10.1155/2022/3954944. eCollection 2022.
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Diphtheria And Tetanus Vaccination History Is Associated With Lower Odds of COVID-19 Hospitalization.白喉和破伤风疫苗接种史与 COVID-19 住院几率降低相关。
Front Immunol. 2021 Oct 7;12:749264. doi: 10.3389/fimmu.2021.749264. eCollection 2021.

本文引用的文献

1
Network medicine framework for identifying drug-repurposing opportunities for COVID-19.用于识别新冠病毒药物再利用机会的网络医学框架。
Proc Natl Acad Sci U S A. 2021 May 11;118(19). doi: 10.1073/pnas.2025581118.
2
Potential Cross-Reactive Immunity to SARS-CoV-2 From Common Human Pathogens and Vaccines.常见人类病原体和疫苗对 SARS-CoV-2 的潜在交叉反应性免疫。
Front Immunol. 2020 Oct 16;11:586984. doi: 10.3389/fimmu.2020.586984. eCollection 2020.
3
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.SARS-CoV-2 刺突蛋白的结构和功能特性:COVID-19 的潜在抗病毒药物研发。
Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. doi: 10.1038/s41401-020-0485-4. Epub 2020 Aug 3.
4
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing.探索 SARS-CoV-2 病毒-宿主-药物相互作用组以进行药物再利用。
Nat Commun. 2020 Jul 14;11(1):3518. doi: 10.1038/s41467-020-17189-2.
5
Does Early Childhood Vaccination Protect Against COVID-19?幼儿接种疫苗能预防新冠病毒吗?
Front Mol Biosci. 2020 Jun 5;7:120. doi: 10.3389/fmolb.2020.00120. eCollection 2020.
6
Higher prevalence of asymptomatic or mild COVID-19 in children, claims and clues.儿童中无症状或轻症新冠病毒感染的患病率更高,说法及线索。
J Med Virol. 2020 Nov;92(11):2257-2259. doi: 10.1002/jmv.26069. Epub 2020 Jun 9.
7
Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2.可能源自蝙蝠的严重急性呼吸综合征冠状病毒 2 型。
Emerg Infect Dis. 2020 Jul;26(7):1542-1547. doi: 10.3201/eid2607.200092. Epub 2020 Jun 21.
8
Universal Screening for SARS-CoV-2 in Women Admitted for Delivery.对入院分娩的女性进行新冠病毒2型普遍筛查。
N Engl J Med. 2020 May 28;382(22):2163-2164. doi: 10.1056/NEJMc2009316. Epub 2020 Apr 13.
9
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2.基于网络的2019新型冠状病毒(2019-nCoV/SARS-CoV-2)药物重新利用研究
Cell Discov. 2020 Mar 16;6:14. doi: 10.1038/s41421-020-0153-3. eCollection 2020.
10
Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections.异源免疫:在自然和疫苗诱导的抗感染中的作用。
Front Immunol. 2019 Nov 8;10:2631. doi: 10.3389/fimmu.2019.02631. eCollection 2019.

接种破伤风疫苗是否有助于减轻 COVID-19 感染的严重程度?

Does tetanus vaccination contribute to reduced severity of the COVID-19 infection?

机构信息

Hewlett Packard Enterprise, USA.

Hewlett Packard Enterprise, USA.

出版信息

Med Hypotheses. 2021 Jan;146:110395. doi: 10.1016/j.mehy.2020.110395. Epub 2020 Nov 28.

DOI:10.1016/j.mehy.2020.110395
PMID:33341328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7695568/
Abstract

We present the hypothesis to the scientific community actively designing clinical trials and recommending public health guidelines to control the pandemic that - "Tetanus vaccination may be contributing to reduced severity of the COVID-19 infection" - and urge further research to validate or invalidate the effectiveness of the tetanus toxoid vaccine against COVID-19. This hypothesis was revealed by an explainable artificial intelligence system unleashed on open public biomedical datasets. As a foundation for scientific rigor, we describe the data and the artificial intelligence system, document the provenance and methodology used to derive the hypothesis and also gather potentially relevant data/evidence from recent studies. We conclude that while correlations may not be reason for causation, correlations from multiple sources is more than a serendipitous coincidence that is worthy of further and deeper investigation.

摘要

我们向积极设计临床试验和推荐公共卫生指南以控制大流行的科学界提出假设,即“破伤风疫苗可能有助于减轻 COVID-19 感染的严重程度”,并敦促进一步研究以验证或否定破伤风类毒素疫苗对 COVID-19 的有效性。这一假设是由一个可解释的人工智能系统在公开的公共生物医学数据集上揭示的。作为科学严谨性的基础,我们描述了数据和人工智能系统,记录了得出假设所使用的出处和方法,并从最近的研究中收集了潜在相关的数据/证据。我们的结论是,虽然相关关系不一定是因果关系的原因,但来自多个来源的相关关系不仅仅是一个偶然的巧合,值得进一步深入调查。