利用新冠病毒中的天然有毒代谢产物
Harnessing the Natural Toxic Metabolites in COVID-19.
作者信息
Bahrami Ali, Taheri Mohammad, Arabestani Mohammad Reza, Soleimani Meysam, Mohammadi Mojdeh, Golabchi Fatemeh, Banitorfi Maryam, Hosseini Seyed Mostafa, Khodabandehlou Sodabe, Nouri Fatemeh
机构信息
Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Scienceaffs, Hamadan, Iran.
出版信息
Evid Based Complement Alternat Med. 2022 Mar 7;2022:3954944. doi: 10.1155/2022/3954944. eCollection 2022.
SARS-CoV-2 is a novel coronavirus and the cause of the recent pandemic; it is an enveloped -coronavirus. SARS-CoV-2 appear in the Wuhan City of China for the first time and outspread worldwide quickly. Due to its person-to-person fast transmission, COVID-19 is becoming a global problem. SARS-CoV-2 enter into cells by using ACE2 receptors that are numerous in the lungs and finally can cause acute respiratory distress syndrome (ARDS). Dry cough, sore throat, fever, body pain, headache, GIT discomfort, diarrhoea, and fatigue are some of the COVID-19 symptoms. There is no definite and certain treatment for disease caused by SARS-CoV-2 till now. Some pharmacological effects of toxins, toxoids, and venoms have been proven, and their effects on some diseases have been evaluated. This study aimed to investigate the role of toxins, toxoids, and venom in the pathophysiology of COVID-19 disease.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型冠状病毒，也是近期大流行的病原体；它是一种包膜冠状病毒。SARS-CoV-2首次出现在中国武汉市，并迅速在全球传播。由于其人际传播速度快，新型冠状病毒肺炎（COVID-19）正成为一个全球性问题。SARS-CoV-2通过利用肺部大量存在的血管紧张素转换酶2（ACE2）受体进入细胞，最终可导致急性呼吸窘迫综合征（ARDS）。干咳、咽痛、发热、身体疼痛、头痛、胃肠道不适、腹泻和疲劳是COVID-19的一些症状。迄今为止，对于由SARS-CoV-2引起的疾病尚无确切的治疗方法。毒素、类毒素和毒液的一些药理作用已得到证实，并且已经评估了它们对某些疾病的影响。本研究旨在探讨毒素、类毒素和毒液在COVID-19疾病病理生理学中的作用。
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