Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.
Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil; Department of Dental Materials and Prosthesis, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.
Oral Oncol. 2021 Apr;115:105116. doi: 10.1016/j.oraloncology.2020.105116. Epub 2020 Dec 17.
Oral melanoma is an extremely aggressive and rare tumor. Commonly, oral melanomas are diagnosed as invasive tumors, which considerably reduces the chances of cure. In situ oral melanomas being exceedingly rare, which makes its clinicopathological and prognostic characteristics poorly known. Herein, we report a case of 67-year-old non-white woman with a large black patch on the maxillary alveolar mucosa. A biopsy was made and microscopical analysis revealed moderate atypical junctional melanocytic. Tumor cells were positive for S100 (Polyclonal), Melan-A (Clone A103) and Melanosome (HMB-45). The diagnosis of in situ oral melanoma was made and the patient was treated surgically with partial maxillectomy and rehabilitated with obturator prosthesis. Although extremely rare in situ melanomas should be considered in the differential diagnosis of non-invasive pigmented lesions of the oral mucosa.
口腔黑色素瘤是一种极具侵袭性且罕见的肿瘤。通常，口腔黑色素瘤被诊断为侵袭性肿瘤，这大大降低了治愈的机会。原位口腔黑色素瘤极为罕见，因此其临床病理和预后特征知之甚少。在此，我们报告一例 67 岁非白人女性，上颌牙槽黏膜有一大块黑斑。进行了活检，显微镜分析显示中度非典型交界性黑色素细胞。肿瘤细胞 S100（多克隆）、Melan-A（克隆 A103）和黑色素体（HMB-45）阳性。诊断为原位口腔黑色素瘤，患者接受了上颌骨部分切除术，并通过义齿修复。虽然原位黑色素瘤极为罕见，但在鉴别诊断口腔黏膜非侵袭性色素性病变时应考虑到。
