Martin W R
Pharmacol Rev. 1983 Dec;35(4):283-323.
The concept of multiple opioid receptors reconciles a large body of clinical and pharmacological data. Recent studies have shown that there are also multiple opioid binding sites. It would appear that there is considerable variability between species in both the specificity and selectivity of opioid receptors. This issue has not been explored systematically regarding opioid binding sites. Better characterization of the pharmacological profiles and receptor binding specificity for different species may help resolve some of the apparent disparities. The number of putative receptors now number nearly a dozen. Already subspecies of mu, kappa, and sigma receptors are being postulated. Both pharmacological and neurochemical methods may reveal even more. Some of the newer kappa agonists differ in their pharmacology from the prototypic kappa agonist ethylketazocine.
多种阿片受体的概念使大量临床和药理学数据相互协调。最近的研究表明，还存在多个阿片结合位点。阿片受体在特异性和选择性方面似乎在不同物种间存在相当大的差异。关于阿片结合位点，这一问题尚未得到系统研究。更好地描述不同物种的药理学特征和受体结合特异性可能有助于解决一些明显的差异。目前推测的受体数量已接近一打。现已假定存在μ、κ和σ受体的亚型。药理学和神经化学方法可能会揭示更多信息。一些新型κ激动剂的药理学特性与原型κ激动剂乙基酮佐辛不同。
