Department of Dermatology, Martini Hospital, Groningen.
Dermatol Online J. 2020 Nov 15;26(11):13030/qt5zf5g9tj.
Aquagenic wrinkling of the palms (AWP) is a rare, acquired condition of the skin, defined by transient rapidly developing white to translucent papules on palms and/or soles after brief exposure to water. Aquagenic wrinkling of the palms is associated with cystic fibrosis (CF). Therefore, the diagnosis of AWP can be important. Etiopathogenesis of AWP is still unclear. Treatment is often unsatisfactory and can be very challenging. This article contributes to the knowledge of AWP as we describe two new cases of aquagenic wrinkling of the palms: one patient with familial history of CF and one patient with AWP that was presumed to be induced by use of non-steroidal anti-inflammatory drugs. In addition, we present a review of the literature on drug-induced AWP.
手掌性水致皱褶（Aquagenic wrinkling of the palms，AWP）是一种罕见的获得性皮肤疾病，其特征是手掌和/或脚底在短暂暴露于水后迅速出现短暂的白色至半透明丘疹。手掌性水致皱褶与囊性纤维化（cystic fibrosis，CF）有关。因此，AWP 的诊断可能很重要。AWP 的发病机制尚不清楚。治疗往往不尽如人意，并且极具挑战性。本文通过描述两例新的手掌性水致皱褶病例，为 AWP 的相关知识做出贡献：一例患者有 CF 的家族史，另一例患者的 AWP 被认为是由使用非甾体抗炎药引起的。此外，我们还对药物诱导的 AWP 的文献进行了综述。
