Department of Neurology, Pomeranian Medical University in Szczecin, Poland.
Department of Applied and Clinical Physiology, Collegium Medicum, University of Zielona Gora, Poland.
Mediators Inflamm. 2020 Dec 3;2020:6676247. doi: 10.1155/2020/6676247. eCollection 2020.
The neurotrophin brain-derived neurotrophic factor (BDNF) affects poststroke functional outcome, neurogenesis, neuroprotection, and neuroplasticity. Its level is related to the diet and nutritional status, and more specifically, it is free fatty acids (FFAs) and eicosanoids that can have an impact on the BDNF level. The aim of this study was to analyze the potential impact of FFAs and eicosanoids on the BDNF level in stroke patients. . Seventy-three ischemic stroke patients were prospectively enrolled in the study. Laboratory tests were performed in all subjects, including the levels of FFAs, eicosanoids, and BDNF. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography, while BDNF was evaluated by the immune-enzymatic method (ELISA).
The plasma level of BDNF negatively correlated with C22:1n9 13 erucic acid, C18:3n3 linolenic acid (ALA), and lipoxin A4 15-epi-LxA4. A direct association was observed in relation to BDNF and C16:1 palmitoleic acid and C20:3n6 eicosatrienoic acid (dihomo-gamma-linolenic acid (DGLA)).
Saturated fatty acids and omega-3 and omega-9 erucic acids can affect signaling in the BDNF synthesis resulting in the decrease in BDNF. There is a beneficial effect of DGLA on the BDNF level, while the effect of ALA on BDNF can be inhibitory. Specialized proresolving lipid mediators can play a role in the BDNF metabolism. BDNF can interact with inflammation as the risk factor in the cardiovascular disorders, including stroke.
神经营养因子脑源性神经营养因子（BDNF）影响卒中后的功能预后、神经发生、神经保护和神经可塑性。其水平与饮食和营养状况有关，更具体地说，是游离脂肪酸（FFAs）和类二十烷酸可以影响 BDNF 水平。本研究旨在分析 FFAs 和类二十烷酸对卒中患者 BDNF 水平的潜在影响。
前瞻性纳入 73 例缺血性卒中患者进行研究。所有受试者均进行实验室检查，包括 FFAs、类二十烷酸和 BDNF 水平。通过气相色谱法和液相色谱法测定 FFAs 和炎症代谢物，通过免疫酶法（ELISA）评估 BDNF。
BDNF 血浆水平与 C22:1n9 13 反式-13 二十二碳烯酸、C18:3n3 亚麻酸（ALA）和脂氧素 A4 15-epi-LxA4 呈负相关。BDNF 与 C16:1 棕榈油酸和 C20:3n6 二十碳三烯酸（二同型-γ-亚麻酸（DGLA））呈直接相关。
饱和脂肪酸和 ω-3 和 ω-9 芥酸可以影响 BDNF 合成的信号转导，导致 BDNF 减少。DGLA 对 BDNF 水平有有益影响，而 ALA 对 BDNF 的作用可能是抑制性的。专门的促解决脂质介质可以在 BDNF 代谢中发挥作用。BDNF 可以与炎症相互作用，作为包括卒中在内的心血管疾病的危险因素。
