Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Str. 24, D-07743 Jena, Germany.
Clin Nutr. 2013 Oct;32(5):686-96. doi: 10.1016/j.clnu.2012.12.010. Epub 2012 Dec 28.
BACKGROUND & AIMS: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health.
Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 1.7 mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8 g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3 g n-3 LC-PUFA/d for a period of 10 wks. Blood samples were taken at the beginning and the end of the study period.
Following daily intake of 3 g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE₃, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P < 0.05); the decrease of TAG and increase in HDL were associated with the CD36 genotype.
The observed increase of n-3 LC-PUFA in RBC and plasma lipids due to intake of n-3 LC-PUFA enriched yoghurt resulted in a reduction of cardiovascular risk factors and inflammatory mediators showing that daily consumption of n-3 PUFA enriched yoghurt can be an effective way of supplementing the daily diet and improving cardiovascular health.
本研究旨在探讨富含 n-3LC-PUFA 的酸奶在改善心血管健康方面的价值。
53 名轻至中度高三酰甘油血症患者（TAG≥1.7mmol/L）参与了一项随机、安慰剂对照、双盲、平行设计的研究。受试者每天食用 1）对照酸奶；2）添加 0.8g n-3LC-PUFA/d 的酸奶；或 3）添加 3g n-3LC-PUFA/d 的酸奶，持续 10 周。在研究开始和结束时采集血样。
连续 10 周每天摄入 3g n-3LC-PUFA 后，血浆和红细胞（RBC）中的 n-3LC-PUFA 水平显著升高，同时血浆中 EPA 衍生介质（PGE₃、12-、15-、18-HEPE）也随之增加，而心血管风险因素如高密度脂蛋白（HDL）、TAG、AA/EPA 比值和 n-3 指数均得到改善（P＜0.05）；TAG 的降低和 HDL 的升高与 CD36 基因型有关。
由于摄入富含 n-3LC-PUFA 的酸奶，RBC 和血浆脂质中的 n-3LC-PUFA 增加，导致心血管风险因素和炎症介质减少，这表明每天食用富含 n-3PUFA 的酸奶可以有效补充日常饮食，改善心血管健康。
