荜茇明碱可缓解小鼠结肠炎及结肠炎相关的结直肠癌。
Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer.
作者信息
Huang Jia-Rong, Wang Sheng-Te, Wei Meng-Ning, Liu Kun, Fu Jing-Wen, Xing Zi-Hao, Shi Zhi
机构信息
Department of Cell Biology, Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Affiliated High School of South China Normal University, Guangzhou, China.
出版信息
Front Pharmacol. 2020 Nov 12;11:586885. doi: 10.3389/fphar.2020.586885. eCollection 2020.
Colorectal cancer is one of the most common and lethal cancers in the world. An important causative factor of colorectal cancer is ulcerative colitis. In this study, we investigated the therapeutic effects of piperlongumine (PL) on the dextran sulfate sodium (DSS)-induced acute colitis and azoxymethane (AOM)/DSS-induced colorectal cancer mouse models. Our results showed that PL could inhibit the inflammation of DSS-induced mouse colitis and reduce the number of large neoplasms (diameter >2 mm) of AOM/DSS-induced mouse colorectal cancer by downregulation of proinflammatory cytokines cyclooxygenase-2 and interleukin-6 and epithelial-mesenchymal transition-related factors, β-catenin, and snail expressions, but fail to improve the colitis symptoms and to decrease the incidence of colonic neoplasms and the number of small neoplasms (diameter <2 mm). These data suggested that PL might be an effective agent in treating colitis and colorectal cancer.
结直肠癌是世界上最常见且致命的癌症之一。溃疡性结肠炎是结直肠癌的一个重要致病因素。在本研究中，我们调查了胡椒碱（PL）对葡聚糖硫酸钠（DSS）诱导的急性结肠炎和氧化偶氮甲烷（AOM）/DSS诱导的结直肠癌小鼠模型的治疗效果。我们的结果表明，PL可通过下调促炎细胞因子环氧合酶-2和白细胞介素-6以及上皮-间质转化相关因子β-连环蛋白和蜗牛蛋白的表达，抑制DSS诱导的小鼠结肠炎炎症，并减少AOM/DSS诱导的小鼠结直肠癌中大型肿瘤（直径>2毫米）的数量，但未能改善结肠炎症状，也未能降低结肠肿瘤的发生率和小型肿瘤（直径<2毫米）的数量。这些数据表明，PL可能是治疗结肠炎和结直肠癌的有效药物。
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