在患有中枢敏化障碍的新西兰女性中发现口腔健康不佳、口腔微生物群与疼痛之间的关联：一项前瞻性临床研究。

An association between poor oral health, oral microbiota, and pain identified in New Zealand women with central sensitisation disorders: a prospective clinical study.

作者信息

Erdrich Sharon, Gelissen Ingrid C, Vuyisich Momchilo, Toma Ryan, Harnett Joanna E

机构信息

Faculty of Medicine and Health, Sydney Pharmacy School, The University of Sydney, Sydney, NSW, Australia.

Viome Life Sciences, Bothell, WA, United States.

出版信息

Front Pain Res (Lausanne). 2025 Apr 9;6:1577193. doi: 10.3389/fpain.2025.1577193. eCollection 2025.

DOI:10.3389/fpain.2025.1577193

PMID:40270934

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12014678/

Abstract

INTRODUCTION

The portal to the gastrointestinal tract is the oral cavity, with transient and permanent microbial residents. Oral pathogens are implicated in the aetiology of several chronic conditions. To date, the role of oral health and the oral microbiota in the aetiology of pain in sensitisation disorders have not been explored. Here, we examined associations between self-reported oral health, the oral microbiome, and various pain presentations in women.

METHODS

Oral health in women was assessed using the WHO oral health questionnaire. Body pain, migraine, and abdominal pain were determined using validated instruments. Saliva samples were evaluated using metatranscriptomics for relative gene abundance. Demographic and clinical characteristics data were evaluated for relationships between oral health scores, pain measures, and the oral microbiota at three taxa levels.

RESULTS

Participants in the lowest quintiles for oral health were more likely to suffer migraine headaches ( = 23.24, df 4, < 0.001) and higher body pain scores. Four oral pathogenic species were significantly associated with SF36 bodily pain ( < 0.05) after controlling for confounders. Relative abundance of (genus) correlated moderately with oral health scores ( = -0.346, = 0.001), while (genus) and were associated with migraine.

DISCUSSION

Low oral health scores correlated with higher pain scores. Both were associated with higher relative abundance of oral pathobionts. This suggests a potential role for the oral microbiota in the aetiology of pain experienced by women with migraine headache and abdominal and body pain. These findings prompt consideration of an oral microbiome-nervous system axis.

TRIAL REGISTRATION

The study was registered with the Australia and New Zealand Clinical Trials Registry (ANZCTR), registration number ACTRN12620001337965, on 11/12/2020 https://www.anzctr.org.au/, and with the World Health Organisation, UTN: U1111-1258-5108.

摘要

引言

胃肠道的入口是口腔，其中有短暂和常驻的微生物群落。口腔病原体与多种慢性疾病的病因有关。迄今为止，口腔健康和口腔微生物群在致敏性疾病疼痛病因中的作用尚未得到探索。在此，我们研究了女性自我报告的口腔健康、口腔微生物群与各种疼痛表现之间的关联。

方法

使用世界卫生组织口腔健康问卷评估女性的口腔健康状况。使用经过验证的工具确定身体疼痛、偏头痛和腹痛情况。使用宏转录组学评估唾液样本中相对基因丰度。在三个分类水平上评估人口统计学和临床特征数据，以了解口腔健康评分、疼痛指标和口腔微生物群之间的关系。

结果

口腔健康处于最低五分位数的参与者更有可能患偏头痛（χ² = 23.24，自由度4，P < 0.001）且身体疼痛评分更高。在控制混杂因素后，四种口腔致病物种与SF36身体疼痛显著相关（P < 0.05）。某属（属名）的相对丰度与口腔健康评分中度相关（r = -0.346，P = 0.001），而另一属（属名）和某菌属与偏头痛有关。