The Joint Research Center of Guangzhou University and Keele University for Gene Interference and Application, School of Life Science, Guangzhou University, Guangzhou 510006, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Oxid Med Cell Longev. 2020 Dec 2;2020:5721258. doi: 10.1155/2020/5721258. eCollection 2020.
Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However, due to insufficient blood flow and oxygen (O) supply in solid tumors, hypoxia is caused, leading to decreased sensitivity of tumor cells and poor therapeutic effects. In addition, hypoxia will also lead to resistance to most anticancer drugs, accelerate malignant progress, and increase metastasis. In solid tumors, adequate O supply and adequate delivery of anticancer drugs are essential to improve radiotherapy and chemotherapy sensitivity. In recent decades, the researches on relieving tumor hypoxia have attracted researchers' extensive attention and achieved good results. However, as far as we know, there is no detailed review of the researches on alleviating tumor hypoxia. Therefore, in this contribution, we hope to give an overview of the researches on methods to improve tumor hypoxia environment and summarize their effect and application in tumor therapy, to provide a methodological reference for the research and development of new antitumor agents.
癌症是全球范围内的主要疾病负担。近年来，除了手术切除外，放射治疗和化学疗法被认为是治疗实体瘤最有效的方法。这些方法已被引入临床治疗不同起源和阶段的肿瘤。然而，由于实体瘤中的血流和氧气（O）供应不足，会导致缺氧，从而降低肿瘤细胞的敏感性和治疗效果不佳。此外，缺氧还会导致大多数抗癌药物产生耐药性，加速恶性进展并增加转移。在实体瘤中，充足的 O 供应和抗癌药物的充分输送对于提高放射治疗和化学疗法的敏感性至关重要。在过去的几十年中，缓解肿瘤缺氧的研究引起了研究人员的广泛关注并取得了良好的效果。然而，据我们所知，目前还没有关于缓解肿瘤缺氧的研究的详细综述。因此，在本综述中，我们希望概述改善肿瘤缺氧环境的研究，并总结它们在肿瘤治疗中的效果和应用，为新型抗肿瘤药物的研究和开发提供方法学参考。
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