Gong Fei, Chen Jiawen, Han Xiao, Zhao Jiayue, Wang Mengyun, Feng Liangzhu, Li Yonggang, Liu Zhuang, Cheng Liang
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
J Mater Chem B. 2018 Apr 21;6(15):2250-2257. doi: 10.1039/c8tb00070k. Epub 2018 Mar 28.
Improving tumor oxygenation and concentrating X-ray radiation energy inside the tumor have received considerable attention in cancer radiotherapy. Herein, core-shell tantalum oxide@manganese dioxide (TaOx@MnO) nanostructures are prepared as an efficient radiosensitizer for enhancing radiotherapy (RT). In these nanostructures, the TaOx core serves as a RT sensitizer that efficiently concentrates X-ray radiation energy inside the tumor, while the MnO shell may trigger the decomposition of endogenous HO in the tumor microenvironment (TME) to generate oxygen and overcome hypoxia-associated radiation resistance. In vitro and in vivo experiments demonstrated that the synthesized TaOx@MnO-PEG nanostructures could accomplish an excellent synergistic radiotherapy sensitization effect. Furthermore, TaOx@MnO-PEG nanoparticles could also serve as promising agents for MR/CT dual-modal imaging. In brief, our study highlights a new type of multifunctional radiosensitizer agent to enhance radiotherapy treatment by means of simultaneously concentrating radiation energy inside tumors and overcoming tumor hypoxia, promising for applications in tumor radiotherapy.
改善肿瘤氧合以及在肿瘤内部集中X射线辐射能量在癌症放射治疗中受到了广泛关注。在此，制备了核壳结构的氧化钽@二氧化锰（TaOx@MnO）纳米结构作为一种有效的放射增敏剂，用于增强放射治疗（RT）。在这些纳米结构中，TaOx核作为放射增敏剂，有效地将X射线辐射能量集中在肿瘤内部，而MnO壳可能触发肿瘤微环境（TME）中内源性H₂O₂的分解以产生氧气并克服缺氧相关的辐射抗性。体外和体内实验表明，合成的TaOx@MnO-PEG纳米结构能够实现优异的协同放射治疗增敏效果。此外，TaOx@MnO-PEG纳米颗粒还可作为有前景的MR/CT双模态成像剂。简而言之，我们的研究突出了一种新型多功能放射增敏剂，通过同时在肿瘤内部集中辐射能量和克服肿瘤缺氧来增强放射治疗，有望应用于肿瘤放射治疗。
