Iida Shohei, Sugioka Kyoko, Kondo Makoto, Matsushima Yoshiaki, Mizutani Kento, Habe Koji, Yamanaka Keiichi
Department of Dermatology, Mie University, Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
Case Rep Dermatol Med. 2020 Dec 2;2020:6682694. doi: 10.1155/2020/6682694. eCollection 2020.
Verruca vulgaris is an infectious disease caused by the human papillomavirus and characterized by hyperkeratotic papules or plaques with a clear boundary. Seborrheic keratosis is a commonly encountered lesion on the face, trunk, or extremities and is described as seborrheic verruca because of its clinical similarity to warts; furthermore, it is occasionally associated with immune suppression, especially in cases of Leser-trélat syndrome. Although these diseases are frequently found in healthy individuals, they typically show a good response to cryotherapy. However, cases in immunosuppressed patients are intractable to therapy. Overall immune status is evaluated via complete blood count (CBC); however, white blood count does not show the exact immune ability, and NK cell activity is often decreased in cases of malignancy. Here, we present two cases of exacerbated verruca vulgaris and seborrheic verruca observed in patients with malignancy. Although the patients seemed to be in good condition and had a normal CBC, immunosuppression was suspected based on the degree of skin rashes. NK cell activity was decreased in both patients, and both cases had malignancy. The measurement of NK cell activity may be a useful approach to evaluate immune status.
寻常疣是一种由人乳头瘤病毒引起的传染病，其特征为边界清晰的角化过度丘疹或斑块。脂溢性角化病是一种常见于面部、躯干或四肢的病变，因其临床症状与疣相似而被称为脂溢性疣；此外，它偶尔与免疫抑制有关，尤其是在Leser-Trélat综合征的病例中。虽然这些疾病在健康个体中很常见，但它们通常对冷冻疗法反应良好。然而，免疫抑制患者的病例对治疗很棘手。通过全血细胞计数（CBC）评估整体免疫状态；然而，白细胞计数并不能显示确切的免疫能力，并且在恶性肿瘤病例中自然杀伤（NK）细胞活性通常会降低。在此，我们报告两例在恶性肿瘤患者中观察到的寻常疣和脂溢性疣加重的病例。尽管患者看起来状况良好且CBC正常，但基于皮疹程度怀疑存在免疫抑制。两名患者的NK细胞活性均降低，且两例均患有恶性肿瘤。测量NK细胞活性可能是评估免疫状态的一种有用方法。
