Baboli Mehran, Zhang Jin, Kim Sungheon Gene
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Curr Pathobiol Rep. 2019 Dec;7(4):129-141. doi: 10.1007/s40139-019-00204-7. Epub 2019 Dec 2.
This article is to review recent technical developments and their clinical applications in cancer imaging quantitative measurement of cellular and vascular properties of the tumors.
Rapid development of fast Magnetic Resonance Imaging (MRI) technologies over last decade brought new opportunities in quantitative MRI methods to measure both cellular and vascular properties of tumors simultaneously.
Diffusion MRI (dMRI) and dynamic contrast enhanced (DCE)-MRI have become widely used to assess the tissue structural and vascular properties, respectively. However, the ultimate potential of these advanced imaging modalities has not been fully exploited. The dependency of dMRI on the diffusion weighting gradient strength and diffusion time can be utilized to measure tumor perfusion, cellular structure, and cellular membrane permeability. Similarly, DCE-MRI can be used to measure vascular and cellular membrane permeability along with cellular compartment volume fractions. To facilitate the understanding of these potentially important methods for quantitative cancer imaging, we discuss the basic concepts and recent developments, as well as future directions for further development.
本文旨在回顾肿瘤细胞和血管特性的癌症成像定量测量方面的最新技术进展及其临床应用。
过去十年快速磁共振成像（MRI）技术的迅速发展为定量MRI方法带来了新机遇，使其能够同时测量肿瘤的细胞和血管特性。
扩散加权磁共振成像（dMRI）和动态对比增强（DCE）-MRI已分别广泛用于评估组织结构和血管特性。然而，这些先进成像模式的最终潜力尚未得到充分利用。dMRI对扩散加权梯度强度和扩散时间的依赖性可用于测量肿瘤灌注、细胞结构和细胞膜通透性。同样，DCE-MRI可用于测量血管和细胞膜通透性以及细胞区室体积分数。为便于理解这些在癌症定量成像中可能很重要的方法，我们讨论了其基本概念、最新进展以及进一步发展的未来方向。
