Valor Luis M, Hervás-Corpión Irati
Unidad de Investigación, Hospital Universitario Puerta del Mar, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
Front Oncol. 2020 Dec 2;10:602378. doi: 10.3389/fonc.2020.602378. eCollection 2020.
Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms.
胶质瘤干细胞（GSCs）因其自我更新和增殖特性，在胶质母细胞瘤（GBs）的形成、持续存在和复发中起着关键作用。尽管GSCs与神经干细胞（NSCs）具有细胞和分子特征，但GSCs显示出独特的转录和表观遗传特征，这可能解释了它们在GB中的相关作用，并可能构成新型治疗方法的可药物作用靶点。在这篇综述中，我们将总结GSCs中有关表观遗传依赖性机制的最重要发现。
