Meng Jiaqi, Wei Ling, Zhang Keke, He Wenwen, Lu Yi, Zhu Xiangjia
Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
National Health Commission Key Laboratory of Myopia (Fudan University), Shanghai, China.
Front Med (Lausanne). 2020 Dec 2;7:595544. doi: 10.3389/fmed.2020.595544. eCollection 2020.
To develop a photographic classification for cilioretinal arteries and to investigate its association with myopic macular degeneration (MMD). One thousand six hundred ninety-two highly myopic eyes of 1,692 patients were included. The presence of a cilioretinal artery was determined by fundus photographs, and a photographic classification was proposed. MMD was classified according to the International META-PM Classification. Associations of the cilioretinal artery and its classifications with MMD and visual acuity were analyzed. Of the eyes tested, 245 (14.5%) had a cilioretinal artery. The cilioretinal arteries were classified into four categories (temporal "cake-fork," 35.92%; temporal "ribbon," 53.47%; "multiple," 6.53%; "nasal," 4.08%) and 3 distributions based on whether its visible branches reached the central foveal area. Eyes with cilioretinal arteries had significantly less MMD of grade ≥3 and better visual acuity than those without ( < 0.01). Multiple linear regression analysis showed that younger age, male sex, shorter axial length, and the presence of a cilioretinal artery were associated with better visual acuity in highly myopic eyes (all < 0.05). The "nasal" category presented more MMD with grade ≥3 and worse visual acuity than the other categories ( < 0.05), whereas the "multiple" category contained no eyes with MMD grade ≥3. The cilioretinal arteries reaching the central foveal area showed less MMD of grade ≥3 and better visual acuity than those not ( < 0.05). We propose a photographic classification for cilioretinal arteries that has good clinical relevance to visual functions. The cilioretinal artery may potentially afford protection against MMD.
建立一种视网膜睫状动脉的影像分类方法，并研究其与近视性黄斑变性（MMD）的关联。纳入1692例患者的1692只高度近视眼。通过眼底照片确定视网膜睫状动脉的存在，并提出一种影像分类方法。MMD根据国际META-PM分类法进行分类。分析视网膜睫状动脉及其分类与MMD和视力的关联。在所检测的眼中，245只（14.5%）有视网膜睫状动脉。视网膜睫状动脉分为四类（颞侧“蛋糕叉”型，35.92%；颞侧“带状”型,53.47%；“多条”型，6.53%；“鼻侧”型，4.08%），并根据其可见分支是否到达中央凹区域分为三种分布类型。有视网膜睫状动脉的眼比没有的眼≥3级MMD明显更少且视力更好（<0.01）。多元线性回归分析显示，年龄较小、男性、眼轴较短以及存在视网膜睫状动脉与高度近视眼较好的视力相关（均<0.05）。“鼻侧”型比其他类型有更多≥3级的MMD且视力更差（<0.05），而“多条”型中没有≥3级MMD的眼。到达中央凹区域的视网膜睫状动脉比未到达的显示出更少的≥3级MMD且视力更好（<0.05）。我们提出一种视网膜睫状动脉的影像分类方法，其与视觉功能具有良好的临床相关性。视网膜睫状动脉可能对MMD具有潜在的保护作用。
