Liu Jung-Tung, Su Pen-Hua
Department of Neurosurgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Department of School of Medicine, Chung-Shan Medical University, Taichung 40201, Taiwan.
World J Clin Cases. 2020 Nov 26;8(22):5773-5780. doi: 10.12998/wjcc.v8.i22.5773.
Stroke is one of the leading causes of death and disability worldwide. In patients suffering from strokes and other acute brain injuries, the prevalence of pituitary dysfunction is high, and growth hormone deficiency is commonly found. Previous studies have demonstrated that administration of recombinant human growth hormone provides adult growth hormone deficiency (AGHD) patients with beneficial effects such as improving body compositions and quality of life. Nevertheless, other physiological benefits of growth hormone substitution are still controversial and inconclusive.
A female with a history of hypertension suffered intracranial hemorrhage, intraventricular hemorrhage, and hydrocephalus at 56 years of age. Her mobility, fluency of speech, and mentality were impaired ever since the event occurred. After five years, the 61-year-old patient was further diagnosed with AGHD and received six-month growth hormone replacement therapy (GHRT). After six months of GHRT, the patient's body composition was improved. A substantial improvement in Mini-Mental State Examination score was also observed, accompanying with ameliorations in mobility, fluency of speech, and mentality.
In addition to improvements in body composition, GHRT for AGHD may provide further beneficial effects in patients with cognitive or motor impairments due to intracerebral hemorrhage.
中风是全球死亡和残疾的主要原因之一。在中风和其他急性脑损伤患者中，垂体功能障碍的患病率很高，且常发现生长激素缺乏。先前的研究表明，给予重组人生长激素可为成人生长激素缺乏症（AGHD）患者带来有益效果，如改善身体成分和生活质量。然而，生长激素替代的其他生理益处仍存在争议且尚无定论。
一名有高血压病史的女性在56岁时发生颅内出血、脑室内出血和脑积水。自发病以来，她的行动能力、言语流畅度和智力均受到损害。五年后，这位61岁的患者被进一步诊断为AGHD，并接受了为期六个月的生长激素替代疗法（GHRT）。经过六个月的GHRT治疗后，患者的身体成分得到改善。简易精神状态检查表评分也有显著提高，同时行动能力、言语流畅度和智力也有所改善。
对于AGHD患者，生长激素替代疗法除了能改善身体成分外，还可能对因脑出血导致认知或运动障碍的患者带来进一步的有益效果。
