Gupta Abhaya, Singh Neetu, Kumar Anil, Verma Umesh Pratap, Verma Ajay Kumar, Shyam Hari, Lal Nand, Kant Surya, Kumari Ankur
Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, India.
Department of Molecular Biology, Center for Advanced Research, King George's Medical University, Uttar Pradesh, Lucknow, India.
Mol Biol Res Commun. 2020 Dec;9(4):169-172. doi: 10.22099/mbrc.2020.37397.1508.
The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes and ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e (P<0.0001) in B+CP while (P<0.0001), (P=0.0003), (P<0.0001), (P=0.0003), (P<0.0001) and (P=0.0004) in CP group. gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.
该研究旨在调查印度中北部人群中患有慢性牙周炎的支气管扩张症患者牙龈组织中靶向炎症免疫反应基因的差异表达。从30名全身健康的慢性牙周炎患者（CP）、30名患有慢性牙周炎的支气管扩张症患者（B+CP）、3名牙龈健康的全身健康者（健康对照；HC）和3名牙龈健康的支气管扩张症患者（支气管扩张症对照；BC）中收集牙龈组织。统计分析显示，与B+CP相比，CP组中有7个基因显著上调，即B+CP组中的（P<0.0001），而CP组中的（P<0.0001）、（P=0.0003）、（P<0.0001）、（P=0.0003）、（P<0.0001）和（P=0.0004）。基因可能是患有慢性牙周炎的支气管扩张症患者的潜在遗传标志物。
