Urizar Guido G, Hernandez Hugo Sanchez, Rayo Jessica, Bhansali Shekhar
Department of Psychology, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA, 90840-0901, USA.
Department of Electrical & Computer Engineering, Florida International University, 10555 West Flagler St. EC 3900, Miami, FL, 33174, USA.
Neurobiol Stress. 2020 Oct 20;13:100263. doi: 10.1016/j.ynstr.2020.100263. eCollection 2020 Nov.
Recent advances in sensor technology allow for the detection of salivary cortisol levels in real-time, yet studies are needed to test their reliability in clinically at-risk populations. This study examined whether a new electrochemical sensor reliably detected cortisol patterns, compared to a conventional immunoassay test (i.e., ELISA), among women and men with low and high depressive symptoms who participated in the Trier Social Stress Test (TSST; a laboratory-based stressor). Results demonstrated that women and those with high depressive symptoms showed lower cortisol levels throughout the TSST overall compared to men and those with low depressive symptoms. The cortisol sensor was highly reliable when compared to the ELISA immunoassay in detecting cortisol responses to the TSST for both women and men and for participants with low and high depressive symptoms. These results suggest that the sensor is a promising tool for assessing real-time cortisol responses to laboratory stressors in at-risk populations.
传感器技术的最新进展使得实时检测唾液皮质醇水平成为可能，但仍需开展研究以测试其在临床高危人群中的可靠性。本研究考察了一种新型电化学传感器与传统免疫分析测试（即酶联免疫吸附测定法，ELISA）相比，能否在参与特里尔社会应激测试（TSST，一种基于实验室的应激源）的有低、高抑郁症状的男性和女性中可靠地检测皮质醇模式。结果表明，与男性和低抑郁症状者相比，女性和高抑郁症状者在整个TSST过程中皮质醇水平总体较低。在检测男性和女性以及低、高抑郁症状参与者对TSST的皮质醇反应时，与ELISA免疫分析相比，皮质醇传感器具有高度可靠性。这些结果表明，该传感器是评估高危人群对实验室应激源的实时皮质醇反应的一种有前景的工具。
