Mikus Elisa, Calvi Simone, Brega Carlotta, Zucchetta Fabio, Tripodi Alberto, Pin Maurizio, Manfrini Marco, Cimaglia Paolo, Masiglat Joyce, Albertini Alberto
Cardiovascular Department, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Ravenna, Italy.
Biostatistics and Epidemiology Unit, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Ravenna, Italy.
J Card Surg. 2021 Feb;36(2):582-588. doi: 10.1111/jocs.15267. Epub 2020 Dec 20.
Ministernotomy and right minithoracotomy are well-known minimally invasive approaches for aortic valve replacement (AVR); however, controversial opinions exist for their utilization in obese patients. The aim of this study is to check a potential positive role of minimally invasive surgery in this population.
From January 2010 to November 2019, 613 obese patients (defined by a body mass index ≥30) underwent isolated AVR at our institution. Surgical approach included standard median sternotomy (176 patients), partial upper sternotomy (271 patients), or right anterior minithoracotomy (166 patients). Intra- and postoperative data were retrospectively collected.
Patients treated with minimally invasive approaches had shorter cardiopulmonary bypass time (p = .012) and aortic cross-clamp time (p = .022), mainly due to the higher utilization of sutureless valve implantation. They also presented advantages in terms of reduced postoperative ventilation time (p = .010), incidence of wound infection (p = .009), need of inotropic support (p = .004), and blood transfusion (p = .001). The univariable logistic regression showed the traditional full sternotomy approach as compared with ministernotomy (p = .026), active smoking (p = .009), peripheral vascular disease (p = .003), ejection fraction (p = .026), as well Logistic European system for cardiac operative risk evaluation (EuroSCORE; p = .015) as factors associated with hospital mortality. The multivariable logistic regression adjusted for the logistic EuroSCORE revealed that surgical approaches do not influence hospital mortality.
Obese patients with severe aortic valve pathology can be treated with minimally invasive approaches offering a less biological insult and reduced postoperative complications, but without impact on hospital mortality.
迷你胸骨切开术和右胸小切口是主动脉瓣置换术(AVR)中广为人知的微创方法;然而,对于其在肥胖患者中的应用存在争议。本研究的目的是检验微创手术在该人群中的潜在积极作用。
2010年1月至2019年11月,613例肥胖患者(定义为体重指数≥30)在我院接受单纯AVR。手术方式包括标准正中胸骨切开术(176例患者)、部分上胸骨切开术(271例患者)或右前小切口开胸术(166例患者)。回顾性收集术中及术后数据。
采用微创方法治疗的患者体外循环时间(p = 0.012)和主动脉阻断时间(p = 0.022)较短,主要原因是无缝合瓣膜植入的使用率较高。他们在术后通气时间缩短(p = 0.010)、伤口感染发生率(p = 0.009)、使用血管活性药物支持的需求(p = 0.004)和输血(p = 0.001)方面也具有优势。单因素逻辑回归显示,与迷你胸骨切开术相比,传统的全胸骨切开术方法(p = 0.026)、主动吸烟(p = 0.009)、外周血管疾病(p = 0.003)、射血分数(p = 0.026)以及心脏手术风险评估的逻辑欧洲系统(EuroSCORE;p = 0.015)是与医院死亡率相关的因素。调整逻辑EuroSCORE后的多因素逻辑回归显示手术方式不影响医院死亡率。
患有严重主动脉瓣病变的肥胖患者可以采用微创方法治疗,这种方法对机体的损伤较小,术后并发症减少,但对医院死亡率没有影响。