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肥胖患者经胸骨上段部分劈开行主动脉瓣置换术获益如何?

Do obese patients benefit from isolated aortic valve replacement through a partial upper sternotomy?

机构信息

Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fujian Province University, Fuzhou, Fujian, China.

出版信息

J Cardiothorac Surg. 2022 Aug 3;17(1):179. doi: 10.1186/s13019-022-01926-3.

Abstract

OBJECTIVE

Controversial opinions exist for aortic valve replacement (AVR) through partial upper sternotomy in obese patients. Moreover, this study sought to investigate the potential clinical advantage of partial upper sternotomy aortic valve replacement (mini-AVR) over conventional full sternotomy aortic valve replacement (con-AVR) in obese patients.

METHODS

This was a retrospective and observational study. From January 2015 to December 2020, a total of 184 obese [body mass index (BMI) ≥ 30 kg  m] patients undergoing isolated primary AVR were included: 98 patients underwent conventional full sternotomy, and 86 patients underwent partial upper sternotomy. Propensity score (PS) matching was applied to eliminate the bassline imbalances in the mini-AVR and the con-AVR groups.

RESULTS

After one-to-one propensity score matching, two groups of 60 patients were obtained. No in-hospital death occurred in the two groups. In addition, cardiopulmonary bypass time and total operative time were similar across the 2 groups, but the aortic cross-clamp time was significantly shorter in the con-AVR group (P = .0.022). The amount of mediastinal drainage at 48 h after surgery (P =  0.018) and postoperative blood transfusions (P =  0.014) were significantly lower in the mini-AVR group. There was no difference in ventilation time (P = .0.145), but a shorter intensive care unit stay time (P =  0.021) in the mini-AVR group.

CONCLUSION

This study demonstrates that aortic valve replacement through a mini-AVR in obese patients is a safe and effective procedure. It outperformed con-AVR in terms of blood loss, blood product transfusion, and ICU stay.

摘要

目的

经胸骨上段部分劈开行主动脉瓣置换术(AVR)在肥胖患者中存在争议。此外,本研究旨在探讨经胸骨上段部分劈开行主动脉瓣置换术(mini-AVR)相对于传统全胸骨劈开行主动脉瓣置换术(con-AVR)在肥胖患者中的潜在临床优势。

方法

这是一项回顾性观察性研究。2015 年 1 月至 2020 年 12 月,共有 184 例肥胖(体重指数(BMI)≥30 kg/m²)患者接受了单纯原发性 AVR:98 例行传统全胸骨劈开,86 例行胸骨上段部分劈开。采用倾向评分(PS)匹配消除 mini-AVR 和 con-AVR 组之间的基线不平衡。

结果

经 1:1 倾向评分匹配后,两组各 60 例患者。两组均无院内死亡。此外,两组体外循环时间和总手术时间相似,但 con-AVR 组主动脉阻断时间明显缩短(P=0.022)。术后 48 小时纵隔引流量(P=0.018)和术后输血(P=0.014)显著减少。两组通气时间无差异(P=0.145),但 mini-AVR 组 ICU 停留时间较短(P=0.021)。

结论

本研究表明,肥胖患者经 mini-AVR 行主动脉瓣置换术是一种安全有效的方法。与 con-AVR 相比,mini-AVR 在出血量、输血和 ICU 停留时间方面表现更好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6339/9351141/fe2cb75f0a7e/13019_2022_1926_Fig1_HTML.jpg

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