Príborský J, Takayama K, Nagai T, Waitzová D, Elis J
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Drug Des Deliv. 1987 Dec;2(2):91-7.
In vitro transdermal absorption of insulin was improved when the penetration enhancers Azone, N-methyl-2-pyrrolidone (NMP) or dimethyl sulfoxide (DMSO) were incorporated in propylene glycol (PG) formulations of the drug. Maximum penetration efficacy depended on optimal concentrations of both the enhancer and PG. Azone and NMP showed maximum efficacy at 0.1% and 12.0% concentration, respectively. In both cases, the optimum concentration of PG was 40.0%. The enhancing ability of DMSO was much lower in comparison with the other two enhancers.
当渗透促进剂氮酮、N-甲基-2-吡咯烷酮（NMP）或二甲基亚砜（DMSO）加入到药物的丙二醇（PG）制剂中时，胰岛素的体外透皮吸收得到改善。最大渗透效果取决于促进剂和PG的最佳浓度。氮酮和NMP分别在0.1%和12.0%浓度时显示出最大效果。在这两种情况下，PG的最佳浓度均为40.0%。与其他两种促进剂相比，DMSO的增强能力要低得多。
