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分娩持续时间与母婴发病率。

Duration of labor and maternal and neonatal morbidity.

机构信息

Denver Health and Hospital Authority, Department of Obstetrics and Gynecology, Denver, CO; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Denver, CO.

University of Colorado School of Medicine, Department of Obstetrics and Gynecology, Aurora, CO.

出版信息

Am J Obstet Gynecol MFM. 2019 Aug;1(3):100032. doi: 10.1016/j.ajogmf.2019.100032. Epub 2019 Aug 5.

Abstract

BACKGROUND

Labor dystocia has been identified as a contributor to the rising cesarean delivery rate in the United States. Allowing more time for vaginal delivery, while being cognizant of maternal and neonatal outcomes, has been identified as a possible strategy to lower cesarean delivery rates.

OBJECTIVE

This study aimed to characterize the relationship between the duration of active phase and second-stage labor and maternal and neonatal morbidity.

STUDY DESIGN

We present a secondary analysis of the Consortium on Safe Labor project. From labors of 66,940 nonanomalous nulliparous term singleton vertex gestations, we excluded labors for which active phase (≥6 cm dilation) or second stage durations could not be calculated and from sites that did not report determinants of morbidity. For each duration of active phase or second stage labor (grouped in 1-hour increments), the adjusted maternal and neonatal composite morbidity was estimated by and compared with the morbidity associated with a duration <1 hour total and a duration of 1 hour shorter.

RESULTS

After exclusions, 48,144 deliveries remained. In adjusted models, compared with labor durations <1 hour total, maternal composite morbidity was significantly higher across active phase and second stage durations (both P<.001); neonatal composite morbidity was higher across the second stage (P<.001), but not active phase (P=.07) duration. These relationships appear linear with no apparent inflection point, and morbidity increases more rapidly. When compared with labor durations 1 hour shorter, significant differences persisted in maternal and neonatal composite morbidity in second stage labor only through 4 and 3 hours, respectively.

CONCLUSION

Maternal and neonatal composite morbidity is greater with longer durations of active and second stage labor; however, no clear cutoff point was determined to suggest truncation of either stage of labor for reasons of morbidity. In addition, incrementally higher morbidities that were noted vs duration <1 hour total were obscured when comparison was made with labors 1 hour shorter, which suggests that focusing on short differences in duration of labor may mask important underlying trends.

摘要

背景

劳动分娩困难已被确定为导致美国剖宫产率上升的原因之一。人们已经认识到,为阴道分娩留出更多时间,同时关注母婴结局,可以作为降低剖宫产率的一种可能策略。

目的

本研究旨在描述活跃期和第二产程时长与母婴发病的关系。

研究设计

我们对安全分娩联盟项目进行了二次分析。在 66940 例非畸形初产妇足月单胎头位妊娠中,我们排除了活跃期(≥6cm 扩张)或第二产程时长无法计算的分娩,以及未报告发病相关因素的分娩地点。对于每个活跃期或第二产程时长(每 1 小时分组),通过与总时长<1 小时和短 1 小时的分娩相关的发病情况比较,估计调整后的母婴复合发病情况。

结果

排除后,有 48144 例分娩仍保留。在调整后的模型中,与总时长<1 小时的分娩相比,活跃期和第二产程时长的产妇复合发病情况显著更高(均 P<.001);新生儿复合发病情况在第二产程更高(P<.001),但在活跃期(P=.07)则不然。这些关系呈线性,没有明显的拐点,发病率增加得更快。与第二产程时长短 1 小时相比,仅在 4 小时和 3 小时时,母婴复合发病情况仍存在显著差异。

结论

活跃期和第二产程时长与产妇和新生儿复合发病情况增加有关;然而,没有确定明确的截断点来建议因发病而缩短分娩的任何阶段。此外,与总时长<1 小时的分娩相比,当与短 1 小时的分娩相比时,递增更高的发病情况被掩盖,这表明关注分娩时长的短差异可能掩盖了重要的潜在趋势。

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