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[透析前慢性肾脏病患者的营养支持]

[Nutritional support for patients with chronic kidney disease at pre-dialysis stages].

作者信息

Kuzmina A V

机构信息

European Medical Center.

出版信息

Ter Arkh. 2020 Jul 9;92(6):117-123. doi: 10.26442/00403660.2020.06.000353.

DOI:10.26442/00403660.2020.06.000353
PMID:33346504
Abstract

Chronic kidney disease (CKD) is characterized by poor outcomes, an increasing frequency of new cases, the need for expensive method of renal replacement therapy at the terminal stage. The main task facing the doctor is slowing the progression of CKD and delay the start of dialysis by applying the nephroprotective strategy, of which diet therapy is an essential part. The key components of the diet for CKD patients are reducing sodium intake to 2.3 g per day in order to improve control of blood pressure (BP), dietary protein restriction adequate to renal function from 0.8 to 0.3 g/kg of body weight per day combined with the prescribing of ketoanalogues of essential amino acids, hyperglycemia control. With the progression of CKD, the main objectives of the diet therapy are the prevention/correction of complications: protein-energy waisting, metabolic acidosis, ensuring sufficient calories, corresponding to the bodys energy expenditures (3035 kcal/kg of body weight per day), limiting phosphate intake to 0.81 g a day, restriction of food potassium. Low-protein diet in combination with ketoanalogues of amino acids, regular monitoring and correction of the nutritional status of patients at the pre-dialysis stages of CKD is an effective and safe method of nephroprotection, which allows delaying the start of dialysis.

摘要

慢性肾脏病(CKD)的特点是预后不佳、新发病例频率不断增加,终末期需要采用昂贵的肾脏替代治疗方法。医生面临的主要任务是通过应用肾脏保护策略减缓CKD的进展并推迟透析开始时间,其中饮食疗法是重要组成部分。CKD患者饮食的关键要素包括:将钠摄入量降至每日2.3克以改善血压(BP)控制;根据肾功能将饮食蛋白质摄入量限制在每天每千克体重0.8至0.3克,并同时开具必需氨基酸的酮类似物;控制高血糖。随着CKD的进展,饮食疗法的主要目标是预防/纠正并发症:蛋白质能量消耗、代谢性酸中毒,确保足够热量,即与身体能量消耗相对应(每天每千克体重30 - 35千卡),将磷摄入量限制在每天0.8 - 1克,限制食物中的钾。在CKD透析前阶段,低蛋白饮食联合氨基酸酮类似物,定期监测和纠正患者营养状况,是一种有效且安全的肾脏保护方法,可推迟透析开始时间。

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