Merget Severin, Catti Lorenzo, Zev Shani, Major Dan T, Trapp Nils, Tiefenbacher Konrad
Department of Chemistry, University of Basel, Mattenstrasse 24a, 4058, Basel, Switzerland.
WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 9201192, Japan.
Chemistry. 2021 Mar 1;27(13):4447-4453. doi: 10.1002/chem.202005046. Epub 2021 Feb 5.
The sizes of available self-assembled hydrogen-bond-based supramolecular capsules and cages are rather limited. The largest systems have volumes of approximately 1400-2300 Å . Herein, we report a large, hexameric cage based on intermolecular amide-amide dimerization. The unusual structure with openings, reminiscent of covalently linked cages, is held together by 24 hydrogen bonds. With a diameter of 2.3 nm and a cavity volume of ∼2800 Å , the assembly is larger than any previously known capsule/cage structure relying exclusively on hydrogen bonds. The self-assembly process in chlorinated, organic solvents was found to be strongly concentration dependent, with the monomeric form prevailing at low concentrations. Additionally, the formation of host-guest complexes with fullerenes (C and C ) was observed.
现有的基于氢键自组装的超分子胶囊和笼的尺寸相当有限。最大的体系体积约为1400 - 2300 ų。在此，我们报道了一种基于分子间酰胺 - 酰胺二聚化的大型六聚体笼。这种具有开口的独特结构让人联想到共价连接的笼，它由24个氢键维系在一起。该组装体直径为2.3 nm，空腔体积约为2800 ų，比以往任何仅依赖氢键的胶囊/笼结构都要大。发现在氯化有机溶剂中的自组装过程强烈依赖浓度，在低浓度下单体形式占主导。此外，还观察到与富勒烯（C₆₀和C₇₀）形成主客体复合物。
